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Invitrogen
Opsin 4 Polyclonal Antibody
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产品信息
PA1-780
应用
建议稀释比
已发表文章
产品规格
种属反应
Mouse,
Rat
已发表种属
C. elegans,
Fruit fly,
Hamster,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues K M(1) N S P S E S R V P S S L T Q D P S F(19) of rat melanopsin.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS with 1mg/mL BSA
内含物
0.05% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
PA1-780 detects mouse and rat melanopsin.
PA1-780 has been successfully used in Western blot, immunofluorescence, and immunocytochemistry procedures. By Western blot, this antibody detects ~53 and ~85 kDa proteins representing overexpressed unglycosylated and glycosylated melanopsin from HEK 293 cells (does not work well on endogenously expressed protein). Immunofluorescence and immunocytochemistry staining of melanopsin in rat retinal ganglion cells (RGCs) can be performed using PA1-780.
PA1-780 immunogen is a synthetic peptide corresponding to residues K M(1) N S P S E S R V P S S L T Q D P S F(19) of rat melanopsin.
靶标信息
Melanopsin is an opsin-like protein found in the retinal ganglion cells of mammals. Melanopsin is believed to be part of a secondary optical system that parallels that of the classic rod and cone system. This second system reports directly to the suprachiasmatic nucleus and is responsible for regulation of circadian rhythms. Melanopsin is believed to be the primary photopigment responsible for the regulation of these circadian rhythms, and Melanopsin knockout mice have been generated which demonstrate decreased capacity to entrain to light and dark cycles.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: LOC721663; Melanopsin; MGC142118; OPN 4; opn4 {ECO:0000312|RGD:621701}; Opsin-4
基因别名: 1110007J02Rik; Gm533; Mop; Mopn; Opn4
UniProt ID: (Mouse) Q9QXZ9, (Rat) Q8R456
Entrez Gene ID: (Mouse) 30044, (Rat) 192223
