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Invitrogen
Orexin A Polyclonal Antibody
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Orexin A Antibody (PA1-18310) in ICC/IF
Scientific reports 2021 -
Figure 1 Parental nursing behaviour activates MCH neuron in the LHA and cell-specific ablation of MCH neurons impairs nursing behaviour in both virgin female and male mice. ( a ) Simultaneous visualisation of c-fos - and MCH-immunoreactive (ir) cells in coronal brain sections at the level of the LHA. Scale bars are 100 um in the above and 20 um in the bottom; a square indicates place of bottom figures in th... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA1-18310
产品规格
种属反应
Bovine,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues C(14) R L Y E L L H G A G N H A A G I L T L(33) of Bovin Orexin A, conjugated to KLH.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
Conc. Not Determined
保存液
whole serum
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
靶标信息
This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: hcrt1; Hypocretin (orexin) neuropeptide; hypocretin-1; orexin; precursor of hypocretin neuropeptides; prepro-orexin; preprohypocretin
基因别名: orexin-A
UniProt ID: (Bovine) P56717, (Rat) O55232
Entrez Gene ID: (Bovine) 281222, (Rat) 25723
neuropeptide signaling pathway
temperature homeostasis
behavioral fear response
phospholipase C-activating G-protein coupled receptor signaling pathway
positive regulation of cytosolic calcium ion concentration
feeding behavior
negative regulation of DNA replication
sleep
response to starvation
eating behavior
drinking behavior
negative regulation of potassium ion transport
regulation of neurotransmitter secretion
behavioral response to ethanol
release of sequestered calcium ion into cytosol
positive regulation of calcium ion transport
negative regulation of transmission of nerve impulse
positive regulation of transmission of nerve impulse
excitatory postsynaptic potential
response to alcohol
positive regulation of cold-induced thermogenesis
response to peptide
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