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Invitrogen
Osteopontin Polyclonal Antibody
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产品信息
PA1-21421
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Human Osteopontin peptide (164-179) (QYPDATDEDITSHMES) KLH conjugated
偶联物
形式
Lyophilized
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
产品详细信息
PA1-21421 cross reacts with human osteopontin peptide (164-179). It does not cross react with human osteopontin peptide (75-90), human osteonectin or human bone sialoprotein.
PA1-21421 has been successfully used in ELISA and Immunohistochemistry (Paraffin) procedures.
PA1-21421 immunogen corresponds to synthetic Human Osteopontin peptide (164-179) (QYPDATDEDITSHMES) KLH conjugated.
靶标信息
Osteopontin is an arginine-glycine-aspartic acid (RGD)-containing glycoprotein that interacts with integrins and CD44 as major receptors. It is a multifunctional protein involved in bone mineralization, cell adhesion, cell migration, chronic inflammatory disease and transformation. Proteolytic cleavage by thrombin and matrix metalloproteinases close to the integrin-binding Arg-Gly-Asp sequence modulates the function of OPN and its integrin binding properties. Thrombin-cleaved fragments of Osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage and provide a novel substrate for plasmin and cathepsin D.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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