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Invitrogen
PACAP-38 Polyclonal Antibody
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FIGURE: 1 / 2
PACAP-38 Antibody (PA5149983) in IHC (P)
Immunohistochemistry analysis of PACAP-38 in paraffin-embedded Mouse Testis tissue. Samples were incubated with PACAP-38 Polyclonal (Product # PA5149983) antibody using a dilution of 10 µg/mL, followed by HRP-Linked Caprine Anti-Rabbit IgG (2 µg/mL) and DAB.
Product Details
PA5149983
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse
Host/Isotype
Rabbit
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Pituitary Adenylate Cyclase Activating Peptide (PACAP) (Met1-Leu175)
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: PACAP; Pituitary adenylate cyclase-activating polypeptide
Gene Aliases: Adcyap1; PACAP
UniProt ID: (Mouse) O70176
Entrez Gene ID: (Mouse) 11516
ovarian follicle development
behavioral fear response
histamine secretion
negative regulation of acute inflammatory response to antigenic stimulus
negative regulation of acute inflammatory response to non-antigenic stimulus
activation of adenylate cyclase activity
positive regulation of cytosolic calcium ion concentration
neuropeptide signaling pathway
nervous system development
regulation of G-protein coupled receptor protein signaling pathway
positive regulation of cell proliferation
positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
positive regulation of gene expression
negative regulation of muscle cell apoptotic process
positive regulation of neuron projection development
sensory perception of pain
cAMP-mediated signaling
positive regulation of cAMP biosynthetic process
neuron projection development
positive regulation of interleukin-6 production
regulation of protein localization
negative regulation of GTPase activity
intracellular signal transduction
negative regulation of potassium ion transport
positive regulation of GTPase activity
negative regulation of cell cycle
positive regulation of protein kinase activity
positive regulation of vasodilation
positive regulation of transcription from RNA polymerase II promoter
ATP metabolic process
positive regulation of synaptic transmission, glutamatergic
regulation of postsynaptic membrane potential
positive regulation of growth hormone secretion
negative regulation of glial cell proliferation
positive regulation of ERK1 and ERK2 cascade
regulation of oligodendrocyte progenitor proliferation
positive regulation of chemokine (C-C motif) ligand 5 production
positive regulation of somatostatin secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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