Search
Invitrogen
PAK2 Recombinant Rabbit Monoclonal Antibody (15H1L7)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
图: 1 / 4
PAK2 Antibody (703248) in ICC/IF
For immunofluorescence analysis, MCF-7 cells were fixed and permeabilized for detection of endogenous PAK2 using Anti-PAK2 Recombinant Rabbit Monoclonal Antibody (Product # 703248, 1:100 dilution) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection and localization of PAK2 protein (green), Panel b) is stained for nuclei (blue) using ProLong™ Diamond Antifade Mountant with DAPI (Product ... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
703248
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
15H1L7
抗原
Peptides corresponding to human PAK2 [1) aa33-aa52 2) aa200-aa219]
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.2-7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Rat.
靶标信息
PAK2 (serine/threonine-protein kinase PAK2) is a serine/threonine kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis, or proliferation. It acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformation change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, serve as targets for the small GTP binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
篇参考文献 (0)
您是否在文献中引用过该产品？请点击下方按钮邮件告知我们。
生物信息学
蛋白别名: Alpha-PAK; Beta-PAK; gamma pak; gamma-PAK; Oligophrenin-3; OPHN3; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; p65-PAK; PAK alpha; PAK beta; PAK gamma; PAK-1; PAK-2; PAK-3; PAK1; PAK3; S6/H4 kinase; unnamed protein product
基因别名: 5330420P17Rik; A130002K10Rik; D16Ertd269e; KNO2; mKIAA4182; PAK-2; PAK65; PAKgamma
UniProt ID: (Human) Q13177, (Mouse) Q8CIN4
Entrez Gene ID: (Human) 5062, (Mouse) 224105
stimulatory C-type lectin receptor signaling pathway
cardiac muscle hypertrophy
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cellular response to starvation
cell migration
adherens junction assembly
intracellular signal transduction
negative regulation of apoptotic process
regulation of MAPK cascade
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
regulation of axonogenesis
regulation of cytoskeleton organization
negative regulation of stress fiber assembly
bicellular tight junction assembly
cellular response to transforming growth factor beta stimulus
regulation of actin filament organization
protein localization to cell-cell junction
positive regulation of extrinsic apoptotic signaling pathway
protein maturation
dendritic spine development
execution phase of apoptosis
positive regulation of execution phase of apoptosis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
