Search
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Proteintech
PANX1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
产品信息
12595-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PANX1 Fusion Protein Ag3174 (126-426 aa encoded by BC016931)
偶联物
形式
Liquid
浓度
0.14 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: FWRFAAAPH ICSDLKFIME ELDKVYNRAI KAAKSARDLD MRDGACSVPG VTENLGQSLW EVSESHFKYP IVEQYLKTKK NSNNLIIKYI SCRLLTLIII LLACIYLGYY FSLSSLSDEF VCSIKSGILR NDSTVPDQFQ CKLIAVGIFQ LLSVINLVVY VLLAPVVVYT LFVPFRQKTD VLKVYEILPT FDVLHFKSEG YNDLSLYNLF LEENISEVKS YKCLKVLENI KSSGQGIDPM LLLTNLGMIK MDVVDGKTPM SAEMREEQGN QTAELQGMNI DSETKANNGE KNARQRLLDS SC (126-426 aa encoded by BC016931)
靶标信息
The pannexin gene family encodes a second class of putative gap junction proteins and are highly conserved in invertebrates and mammals. Pannexins (Panx) are four-pass transmembrane proteins that oligomerize to form large pore ion and metabolite-permeable channels. Pannexin-1 (PANX1) and Pannexin-3 are closely related, while Pannexin-2 is a more distant relation. PANX1 is a transmembrane protein that forms a mechanosensitive ATP-permeable channel between adjacent cells and in the endoplasmic reticulum. PANX1 may play a role as a Ca2+ -leak channel to regulate ER Ca2+ homeostasis and regulates neural stem and progenitor cell proliferation.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: innexin; Pannexin-1; PANX1
基因别名: AI847747; MRS1; PANX1; PX1; UNQ2529; UNQ2529/PRO6028
UniProt ID: (Human) Q96RD7, (Mouse) Q9JIP4
Entrez Gene ID: (Human) 24145, (Mouse) 55991
protease binding
receptor binding
calcium channel activity
leak channel activity
ion channel binding
protein heterodimerization activity
actin filament binding
gap junction hemi-channel activity
scaffold protein binding
actin binding
gap junction channel activity
protein binding
channel activity
wide pore channel activity
response to ischemia
cation transport
calcium ion transport
cell-cell signaling
response to ATP
protein hexamerization
positive regulation of interleukin-1 alpha secretion
positive regulation of interleukin-1 beta secretion
calcium ion transmembrane transport
transport
ion transport
positive regulation of cytokine secretion
transmembrane transport
