Invitrogen

PATZ1 Polyclonal Antibody

Name: PATZ1 Polyclonal Antibody
Brand: Invitrogen
SKU: PA5-87598
Availability: InStock

查看其他6个PATZ1抗体

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

说明书

Certificates

实验方案

问题与答案

技术支持

Additional Information:

抗体检测数据 (1)

图: 1 / 1

PATZ1 Antibody (PA5-87598) in WB

Western blot analysis of PATZ1 in various lysates. Samples were incubated with PATZ1 Polyclonal antibody (Product # PA5-87598) using a dilution of 1:2,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.

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Immunogen image

Immunogen Image PATZ1 Polyclonal Antibody

产品信息

PA5-87598

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:5,000

酶联免疫吸附实验 (ELISA)

1 µg/mL

产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human PATZ1 (NP_0551382)

3D表位/免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.7 mg/mL

70 µg

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

AB_2804278

产品详细信息

Immunogen sequence: PFPSVASSAP PLTGKRGRGR PRKANLLDSM FGSPGGLREA GILPCGLCGK VFTDANRLRQ HEAQHGVTSL QLGYIDLPPP RLGENGLPIS EDPDGPRKRS R; Positive Samples: HT-29, HeLa, MCF7, HL-60, HepG2, Mouse kidney, Mouse spleen, Mouse lung, Rat kidney; Cellular Location: Nucleus

靶标信息

The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t(1;22)(p36. 1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: POZ-, AT hook-, and zinc finger-containing protein 1; POZ-AT hook-zinc finger protein; transcription factor (MAZ-related) MAZR; zi; zinc finger protein 278

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基因别名: 8430401L15Rik; AI447519; Mazr; Patz; Zfp278; Znf278

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Entrez Gene ID: (Rat) 305471, (Mouse) 56218

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功能

RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding chromatin binding metal ion binding protein binding C2H2 zinc finger transcription factor

参与通路

regulation of transcription, DNA-templated transcription from RNA polymerase II promoter spermatogenesis male gonad development regulation of gene expression T cell differentiation positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter negative regulation of transcription, DNA-templated