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Invitrogen
PCGF6 Polyclonal Antibody
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产品信息
PA5-113770
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide directed towards the middle region of human PCGF6
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Affinity chromatography
保存液
PBS with 2% sucrose
内含物
0.09% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: TQPLYNISAN EGTGHFKPLE KKFVRVSGEA TIGHVEKFLR RKMGLDPACQ
For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Predicted homology: Human: 100%
靶标信息
Polycomb group (PcG) proteins form multiprotein complexes that regulate expression patterns of developmental and cell proliferation genes. Several members of the PcG contain ring finger domains and are identified as a subclass of RING finger proteins. The RING-type zinc finger motif is present in a number of viral and eukaryotic proteins and is made of a conserved cysteine-rich domain that is able to bind two zinc atoms. Proteins that contain the RING-type zinc finger conserved domain are generally involved in the ubiquitination pathway of protein degradation. PCGF6 (polycomb group ring finger 6), also known as MBLR or RNF134, is a 350 amino acid nuclear protein that is ubiquitously expressed and contains one RING-type zinc finger. PCGF6 acts as a transcriptional repressor and regulates the level of histone H3K4Me3 by activating SmcY histone demethylase. PCGF6 exists as two alternatively spliced isoforms.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Mel18 and Bmi1-like RING finger; Mel18 and Bmi1-like RING finger protein; Polycomb group RING finger protein 6; RING finger protein 134
基因别名: MBLR; PCGF6; RNF134
UniProt ID: (Human) Q9BYE7
Entrez Gene ID: (Human) 84108
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
zinc ion binding
histone modifying enzyme
