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OriGene
PDE1A Monoclonal Antibody (OTI5C9), TrueMAB™
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PDE1A Antibody (CF803136) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PDE1A (RC205292, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-PDE1A. Positive lysates LY401556 (100 µg) and LC401556 (20 µg) can be purchased separately from OriGene.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
CF803136
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI5C9
抗原
Human recombinant protein fragment corresponding to amino acids 259-545 of human PDE1A produced in E.coli.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Lyophilized
浓度
1 mg/mL
规格
100 µg
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
Cyclic nucleotide phosphodiesterases (PDEs) play a role in signal transduction by regulating intracellular cyclic nucleotide concentrations through hydrolysis of cAMP and/or cGMP to their respective nucleoside 5-prime monophosphates. Members of the PDE1 family, such as PDE1A, are Ca(2+)/calmodulin (see CALM1)that are activated by calmodulin in the presence of Ca(2+) (Michibata et al., 2001).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 61 kDa Cam-PDE; calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A; calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase; HS MGC26303; MGC26303; phosphodiesterase 1A, calmodulin-dependent; phosphodiesterase-1A; unnamed protein product
基因别名: CAM-PDE 1A; CAM-PDE-1A; HCAM-1; HCAM1; HSPDE1A
UniProt ID: (Human) P54750
Entrez Gene ID: (Human) 5136
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
protein binding
phosphoric diester hydrolase activity
3',5'-cyclic-GMP phosphodiesterase activity
calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity
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