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Fabgennix

PDE4 Polyclonal Antibody

查看其他2个PDE4抗体

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说明书
Certificates
实验方案
问题与答案
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说明书
Certificates
实验方案
问题与答案
技术支持
说明书
Certificates
实验方案
问题与答案
技术支持
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产品信息

PD4-101AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
-

免疫组化 (IHC)

1:50-1:250
-

免疫细胞化学 (ICC/IF)

1:50-1:250
-

酶联免疫吸附实验 (ELISA)

1:10,000
-

免疫沉淀 (IP)

1:50-1:250
-

免疫电镜技术 (IM)

1:50-1:200
-
产品规格

种属反应

Chicken, Human, Mouse, Non-human primate, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide common to most PDE4 subtypes: PDE4A, PDE4D, PDE4B

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5-1.5 mg/mL

纯化类型

Affinity chromatography

保存液

proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Ambient (domestic); Wet ice (international)

靶标信息

A phosphodiesterase-4 inhibitor, commonly referred to as a PDE4 inhibitor, is a drug used to block the degradative action of phosphodiesterase 4 on cyclic adenosine monophosphate. It is a member of the larger family of PDE inhibitors. The PDE4 family of enzymes are the most prevalent PDE in immune cells.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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Cite this product

生物信息学

蛋白别名: 3',5'-cyclic AMP phosphodiesterase; alternatively spliced; cAMP phosphodiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4A; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4A; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4A; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP (cAMP)-specific phosphodiesterase; cyclic AMP specific phosphodiesterase family 4 sub-family A isoform 11; cyclic AMP specific phosphodiesterase PDE4A5A; cyclic AMP specific phosphodiesterase PDE4D5A; cyclic nucleotide phosphodiesterase; dunce; long form PDE4A; PDE4A10 cAMP phosphodiesterase; PDE4D1; PDE4D10; PDE4D11; PDE4D2_v1; PDE4D2_v2; PDE4D2_v3; PDE4D6; phosphodiesterase 4A, cAMP specific; phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific (phosphodiesterase E2 dunce homolog, Drosophila); phosphodiesterase 4D, cAMP-specific; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4; similar to Pde4a1; splice variant PDE4D4; testicular tissue protein Li 136; type-IVA cyclic AMP specific phosphodiesterase HPDE4A; unnamed protein product

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基因别名: 9630011N22Rik; ACRDYS2; D9Ertd60e; DPDE2; DPDE3; HSPDE4D; PDE3/IVd; PDE4; PDE43; PDE46; PDE4DN2; PHOSA; STRK1

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UniProt ID: (Human) P27815, (Human) Q08499, (Mouse) O89084, (Rat) P54748, (Rat) P14270, (Mouse) Q01063

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Entrez Gene ID: (Human) 5141, (Chicken) 769469, (Human) 5144, (Mouse) 18577, (Rat) 25638, (Rat) 24627, (Mouse) 238871

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功能
3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding phosphoric diester hydrolase activity cAMP binding 3',5'-cyclic-GMP phosphodiesterase activity calcium channel regulator activity enzyme binding receptor regulator activity beta-2 adrenergic receptor binding ion channel binding ATPase binding scaffold protein binding heterocyclic compound binding cyclic-nucleotide phosphodiesterase activity TPR domain binding phosphodiesterase
参与通路
cAMP catabolic process signal transduction G-protein coupled receptor signaling pathway negative regulation of cAMP/PKA signal transduction regulation of heart rate positive regulation of heart rate regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production negative regulation of heart contraction T cell receptor signaling pathway establishment of endothelial barrier cellular response to cAMP cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle regulation of calcium ion transmembrane transport via high voltage-gated calcium channel sensory perception of smell modulation of synaptic transmission cellular response to xenobiotic stimulus regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway regulation of cAMP/PKA signal transduction response to xenobiotic stimulus ovulation from ovarian follicle positive regulation of protein phosphorylation smooth muscle contraction memory positive regulation of smooth muscle cell migration positive regulation of cell-cell adhesion lung development neutrophil chemotaxis multicellular organism growth positive regulation of smooth muscle cell proliferation leukocyte migration protein-containing complex assembly cellular response to lipopolysaccharide cellular response to follicle-stimulating hormone stimulus cAMP/PKA signal transduction regulation of G-protein coupled receptor protein signaling pathway
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