Invitrogen

PDE4D Polyclonal Antibody

查看其他26个PDE4D抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
PDE4D Polyclonal Antibody

产品信息

PA5-89542

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

1 µg/mL
-
产品规格

种属反应

Human, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant fusion protein containing a sequence corresponding to amino acids 249-518 of human PDE4D (NP_0011841521)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.43 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2805639

产品详细信息

Immunogen sequence: FKLLQEENCD IFQNLTKKQR QSLRKMVIDI VLATDMSKHM NLLADLKTMV ETKKVTSSGV LLLDNYSDRI QVLQNMVHCA DLSNPTKPLQ LYRQWTDRIM EEFFRQGDRE RERGMEISPM CDKHNASVEK SQVGFIDYIV HPLWETWADL VHPDAQDILD TLEDNREWYQ STIPQSPSPA PDDPEEGRQG QTEKFQFELT LEEDGESDTE KDSGSQVEED TSCSDSKTLC TQDSESTEIP LDEQVEEEAV GEEEESQPEA CVIDDRSPDT; Positive Samples: HT-29, A-549, SW480; Cellular Location: Apical cell membrane, Cytoplasm, Membrane, centrosome, cytoskeleton, microtubule organizing center

靶标信息

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: 3',5'-cyclic-AMP phosphodiesterase 4D; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D; cAMP-specific phosphodiesterase PDE4D6; cAMP-specific phosphodiesterase splice variant PDE4D8; DKFZp686M11213; DPDE3; FLJ97311; HGNC:8783; HS PDE4DN2; PDE43; PDE4D3; PDE4D7; Phosphodiesterase 4D cAMP-specific (dunce; phosphodiesterase 4D, cAMP specific; Phosphodiesterase 4D, cAMP-specific (dunce; phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136

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基因别名: ACRDYS2; DPDE3; HSPDE4D; PDE43; PDE4D; PDE4DN2; STRK1

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UniProt ID: (Human) Q08499, (Rat) P14270

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Entrez Gene ID: (Human) 5144, (Rat) 24627

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功能
3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding drug binding enzyme binding cAMP binding beta-2 adrenergic receptor binding ion channel binding metal ion binding ATPase binding scaffold protein binding cyclic-nucleotide phosphodiesterase activity SH3 domain binding protein domain specific binding ubiquitin protein ligase binding phosphodiesterase
参与通路
regulation of heart rate cAMP catabolic process smooth muscle contraction aging regulation of receptor activity regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum cAMP-mediated signaling neutrophil chemotaxis regulation of cAMP metabolic process positive regulation of interferon-gamma production positive regulation of interleukin-2 production positive regulation of interleukin-5 production negative regulation of peptidyl-serine phosphorylation multicellular organism growth negative regulation of heart contraction T cell receptor signaling pathway regulation of ryanodine-sensitive calcium-release channel activity establishment of endothelial barrier cellular response to lipopolysaccharide cellular response to epinephrine stimulus adrenergic receptor signaling pathway regulation of cardiac muscle cell contraction adrenergic receptor signaling pathway involved in positive regulation of heart rate regulation of cell communication by electrical coupling involved in cardiac conduction negative regulation of relaxation of cardiac muscle memory regulation of G-protein coupled receptor protein signaling pathway regulation of protein kinase A signaling positive regulation of smooth muscle cell migration lung development cellular protein complex assembly positive regulation of smooth muscle cell proliferation leukocyte migration cellular response to cAMP
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