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Invitrogen
PDE6 gamma Polyclonal Antibody
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产品信息
PA1-723
应用
建议稀释比
已发表文章
产品规格
已发表种属
Bovine,
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic Peptide: M(1) N L E P P K A E I R S A T R(15) C
偶联物
形式
Liquid
浓度
Conc. Not Determined
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
PA1-723 detects phosphodiesterase 6 gamma (PDE6 gamma) from sheep retinal extract and bovine rod outer segment membranes as well as purified bovine PDE6 gamma.
PA1-723 has been successfully used in Western blot procedures. By Western blot, this antibody detects an ~10 kDa protein representing PDE6 gamma from sheep retinal extract.
The PA1-723 immunizing peptide corresponds to amino acid residues 1-15 from bovine PDE6 gamma. This peptide (Cat. # PEP-150) is available for use in neutralization and control experiments.
靶标信息
The second messengers cAMP and cGMP are key regulatory molecules that are involved in a wide variety of signal transduction pathways. Levels of cAMP and cGMP are regulated by their rate of synthesis by nucleotide cyclases and by their rate of hydrolysis by cyclic nucleotide phosphodiesterases (PDEs). PDEs form a superfamily of enzymes that catalyze the conversion of 3-prime, 5-prime-cyclic nucleotides to the corresponding nucleoside 5-prime-monophosphates. PDE6 is the effector enzyme in the G protein-mediated signal transduction cascade in the visual system. There are five different subunits consisting of rod and cone specific catalytic subunits: alpha' (Cone), alpha (Rod), and beta (Rod), the inhibitory subunit gamma, and subunit delta of unknown function (which likely interacts with many other proteins besides the PDE6 family). The catalytic core of the PDE6 system is comprised of alpha'/alpha' homodimers in the cone and alpha/beta heterodimers in the rod. The C-terminus of both the catalytic and inhibitory subunits is modified by methylation, myristyolation and prenylation which have been shown to be critical for proper complex assembly and membrane association.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
