Invitrogen

PDGFRB Polyclonal Antibody

View all (73) PDGFRB (CD140b) antibodies

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PDGFRB Polyclonal Antibody

Product Details

PA5-96085

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.94 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.09% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2807887

Product Specific Information

Positive Samples: Mouse brain, Mouse lung; Cellular Location: Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein

Immunogen sequence: EVVNFEWTYP RKESGRLVE

Target Information

PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140b; CD140b antigen; PDGF beta chain; PDGF Receptor beta; PDGF-R-beta; PDGFR-1; PDGFR-beta; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; Platelet-derived growth factor receptor, beta; platelet-derived growth factor receptor, beta polypeptide

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Gene Aliases: AI528809; CD140B; IBGC4; IMF1; JTK12; KOGS; PDGFR; PDGFR-1; PDGFR1; PDGFRB; PENTT

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UniProt ID: (Human) P09619, (Rat) Q05030, (Mouse) P05622

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Entrez Gene ID: (Human) 5159, (Rat) 24629, (Mouse) 18596

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Function(s)
protein tyrosine kinase activity platelet activating factor receptor activity platelet-derived growth factor-activated receptor activity platelet-derived growth factor beta-receptor activity Ras guanyl-nucleotide exchange factor activity receptor binding platelet-derived growth factor receptor binding protein binding ATP binding protein kinase binding vascular endothelial growth factor binding phosphatidylinositol 3-kinase binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity platelet-derived growth factor binding protein kinase activity signal transducer activity kinase activity nucleotide binding transmembrane receptor protein tyrosine kinase activity transferase activity transferase activity, transferring phosphorus-containing groups transmembrane signal receptor
Process(es)
MAPK cascade glycosaminoglycan biosynthetic process signal transduction G-protein coupled receptor signaling pathway positive regulation of cell proliferation response to toxic substance positive regulation of phospholipase C activity regulation of phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling positive regulation of smooth muscle cell migration cell migration peptidyl-tyrosine phosphorylation positive regulation of cell migration response to estradiol positive regulation of phosphoprotein phosphatase activity response to retinoic acid regulation of actin cytoskeleton organization positive regulation of collagen biosynthetic process response to fluid shear stress cell migration involved in vasculogenesis metanephric mesenchymal cell migration platelet-derived growth factor receptor-beta signaling pathway positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway aorta morphogenesis cellular response to platelet-derived growth factor stimulus positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway wound healing response to hydrogen peroxide negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of GTPase activity positive regulation of phosphatidylinositol 3-kinase activity response to estrogen positive regulation of mitotic nuclear division phosphatidylinositol metabolic process protein autophosphorylation phosphatidylinositol phosphorylation platelet-derived growth factor receptor signaling pathway phosphatidylinositol-mediated signaling positive regulation of smooth muscle cell proliferation inner ear development positive regulation of chemotaxis cardiac myofibril assembly response to hyperoxia cell chemotaxis cell migration involved in coronary angiogenesis retina vasculature development in camera-type eye positive regulation of ERK1 and ERK2 cascade smooth muscle cell chemotaxis metanephric mesenchyme development metanephric glomerular mesangial cell proliferation involved in metanephros development metanephric glomerular capillary formation metanephric comma-shaped body morphogenesis metanephric S-shaped body morphogenesis positive regulation of calcium ion import positive regulation of reactive oxygen species metabolic process positive regulation of DNA biosynthetic process in utero embryonic development kidney development tissue homeostasis nitrogen compound metabolic process response to organic cyclic compound phosphorylation hemopoiesis adrenal gland development response to lipid intracellular signal transduction skeletal system morphogenesis smooth muscle tissue development regulation of peptidyl-tyrosine phosphorylation metanephric glomerulus morphogenesis protein phosphorylation chemotaxis transmembrane receptor protein tyrosine kinase signaling pathway multicellular organism development cardiac vascular smooth muscle cell differentiation
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