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Invitrogen
PDX1 Monoclonal Antibody (5A5)
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产品信息
MA5-17148
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
5A5
抗原
Purified recombinant fragment of human PDX1 expressed in E. Coli.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.05% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-17148 targets PDX1 in FACS, indirect ELISA, and WB applications and shows reactivity with Human samples.
The MA5-17148 immunogen is purified recombinant fragment of human PDX1 expressed in E. Coli.
MA5-17148 detects PDX1 which has a predicted molecular weight of approximately 30.8kDa.
靶标信息
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DLDBP; E3BP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1
基因别名: GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1
UniProt ID: (Human) P52945
Entrez Gene ID: (Human) 3651
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
transcription factor binding
protein complex binding
protein heterodimerization activity
negative regulation of transcription from RNA polymerase II promoter
liver development
type B pancreatic cell differentiation
glucose metabolic process
generation of precursor metabolites and energy
transcription from RNA polymerase II promoter
smoothened signaling pathway
nitric oxide mediated signal transduction
central nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
response to wounding
organ morphogenesis
response to iron(II) ion
response to chlorate
organ senescence
positive regulation of cell death
morphogenesis of embryonic epithelium
insulin secretion
exocrine pancreas development
organ regeneration
response to vitamin
response to cytokine
response to nicotine
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to drug
glucose homeostasis
response to leucine
positive regulation of DNA binding
positive regulation of transcription from RNA polymerase II promoter
digestive tract development
stem cell differentiation
response to glucocorticoid
detection of glucose
transdifferentiation
response to fatty acid
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of type B pancreatic cell apoptotic process
