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Invitrogen
PEN2 Polyclonal Antibody
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产品信息
PA1-10293
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide, conjugated to KLH, corresponding to the 11 most N-terminal residues of human Pen-2.
偶联物
形式
Lyophilized
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
产品详细信息
This antibody is predicted to react with bovine, rat and Xenopus based on sequence homology. In addition to PEN-2, it also recognizes an unknown protein at ~40kDa.
Reconstitute using 83.3ul of sterile distilled water. After reconstitution, aliquot and store at -20C.
靶标信息
Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processing of the beta-amyloid precursor protein generates neurotoxic amyloid beta peptides, the major component of senile plaques associated with Alzheimer's disease. This gene encodes a protein that is required for Notch pathway signaling, and for the activity and accumulation of gamma-secretase.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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