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PI3-kinase p110 delta Polyclonal Antibody

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PI3-kinase p110 delta Polyclonal Antibody

产品信息

100-401-862

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000
-

酶联免疫吸附实验 (ELISA)

1:4,000-1:20,000
-
产品规格

种属反应

Human, Mouse

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

This antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to a region near the C-terminal of mouse PI3K p110d. This sequence is identical in both mouse and human.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

85 mg/mL

保存液

0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl

内含物

0.01% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Reactivity occurs against mouse PI3K p110d subunit. Cross reactivity is expected against the human protein as the sequence of the immunogen is 100% identical in both human and mouse. Cross reactivity is also expected against rat PI3K p110d.

靶标信息

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: catalytic phosphatidylinositol 3-kinase delta; p100 delta; phosphatidylinositol 3-kinase catalytic subunit delta; phosphatidylinositol 3-kinase p110 delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta; phosphoinositide 3 kinase P110delta; phosphoinositide-3-kinase C; phosphoinositide-3-kinase, catalytic, delta polypeptide variant p37delta; PI3-kinase p110 subunit delta; PI3-kinase subunit delta; PI3K delta; PI3K-delta; PI3K-p110delta; pi3kcd; PI3Kdelta; PI3Kp110delta; ptdIns-3-kinase subunit delta; PtdIns-3-kinase subunit p110-delta

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基因别名: 2410099E07Rik; 2610208K16Rik; APDS; AW545373; IMD14; p110D; P110DELTA; PI3K; PIK3CD

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UniProt ID: (Human) O00329, (Mouse) O35904

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Entrez Gene ID: (Human) 5293, (Mouse) 18707

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功能
protein binding ATP binding 1-phosphatidylinositol-3-kinase activity phosphatidylinositol 3-kinase activity 1-phosphatidylinositol-4-phosphate 3-kinase activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor kinase
参与通路
natural killer cell differentiation cytokine production adaptive immune response mast cell chemotaxis respiratory burst involved in defense response protein phosphorylation phosphatidylinositol biosynthetic process inflammatory response signal transduction positive regulation of gene expression T cell chemotaxis phosphatidylinositol 3-kinase signaling regulation of phosphatidylinositol 3-kinase signaling natural killer cell activation T cell differentiation positive regulation of cell migration neutrophil chemotaxis natural killer cell chemotaxis B cell chemotaxis phosphatidylinositol-3-phosphate biosynthetic process T cell activation B cell activation mast cell degranulation innate immune response phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling T cell receptor signaling pathway B cell receptor signaling pathway mast cell differentiation neutrophil extravasation B cell homeostasis immune system process chemotaxis cell surface receptor signaling pathway phosphorylation cell differentiation platelet activation homeostasis of number of cells defense response to fungus cell chemotaxis
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