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Invitrogen
PINX1 Polyclonal Antibody
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产品信息
PA5-139773
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
形式
Liquid
浓度
0.7 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Gently mix before use. Optimal concentrations and conditions for each application should be determined by the user.
Immunogen sequence: ENETTTTSAF TIQEYFAKRM AALKNKPQVP VPGSDISETQ VERKRGKKRN KEATGKDVES YLQP
Highest antigen sequence indentity to the following orthologs: Rat - 63%, Mouse - 70%.
靶标信息
Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 67-11-3 protein; FLJ20565; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; MGC8850; PIN2 interacting protein 1; pin2-interact; PIN2-interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; Protein 67-11-3; TRF1-interacting protein 1
基因别名: LPTL; LPTS; PINX1
UniProt ID: (Human) Q96BK5
Entrez Gene ID: (Human) 54984
telomere maintenance via telomerase
mitotic metaphase plate congression
negative regulation of cell proliferation
negative regulation of protein ubiquitination
regulation of protein stability
negative regulation of telomere maintenance via telomerase
regulation of telomerase activity
negative regulation of telomerase activity
protein localization to chromosome, telomeric region
protein localization to nucleolus
negative regulation of telomere maintenance via telomere lengthening
positive regulation of telomeric DNA binding
positive regulation of protein localization to nucleolus
