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PIP5K3 Monoclonal Antibody (1D11)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00200576-M02
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
1D11
抗原
PIP5K3 (NP_689884, 342 a.a. approximately 451 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Sandwich ELISA (Recombinant protein).
Immunogen sequence: LQSTEFSETP SPDSDSVNSV EGHSEPSWFK DIKFDDSDTE QIAEEGDDNL ANSASPSKRT SVSSFQSTVD SDSAASISLN VELDNVNFHI KKPSKYPHVP PHPADQKGRR
靶标信息
PIKFYVE belongs to a large family of lipid kinases that alter the phosphorylation status of intracellular phosphatidylinositol. The content of phosphatidylinositol 3,5-bisphosphateP2) in endosomal membranes changes dynamically with fission and fusion events that generate or absorb intracellular transport vesicles. PIKFYVE is the PtdIns(3,5)P2-producing component of a trimolecular complex that tightly regulates the level of PtdIns(3,5)P2. Other components of this complex are the PIKFYVE activator VAC14 and the PtdIns(3,5)P2 phosphatase FIG4. In addition to its phosphoinositide 5-kinase activity, PIKFYVE also has protein kinase activity. For a review, see Shisheva.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: epididymis luminal protein 37; phosphatidylinositol 3-phosphate 5-kinase type III; phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III; phosphoinositide kinase, FYVE finger containing; PIKfyve; PIPkin-III; serine-protein kinase PIKFYVE; type III PIP kinase; unnamed protein product; zinc finger, FYVE domain containing 29
基因别名: FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
UniProt ID: (Human) Q9Y2I7
Entrez Gene ID: (Human) 200576
1-phosphatidylinositol-3-phosphate 5-kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
cholesterol binding
1-phosphatidylinositol-4-phosphate 5-kinase activity
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
metal ion binding
phosphatidylinositol kinase activity
1-phosphatidylinositol-5-kinase activity
phosphatidylinositol-3,5-bisphosphate binding
protein serine kinase activity
protein targeting to membrane
phosphatidylinositol biosynthetic process
receptor-mediated endocytosis
receptor-mediated endocytosis of virus by host cell
antigen processing and presentation of exogenous peptide antigen via MHC class II
neutrophil chemotaxis
melanosome organization
protein localization to nucleus
intracellular signal transduction
phosphatidylinositol-3-phosphate biosynthetic process
peptidyl-serine autophosphorylation
retrograde transport, endosome to Golgi
phosphatidylinositol metabolic process
phagosome maturation
phagosome-lysosome fusion
positive regulation of cGAS/STING signaling pathway
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process
regulation of reactive oxygen species biosynthetic process
phosphatidylinositol 5-phosphate metabolic process
regulation of autophagosome assembly
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