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Invitrogen
PKC iota Polyclonal Antibody
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产品信息
PA5150155
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
分类
Polyclonal
类型
Antibody
抗原
Recombinant Protein Kinase C Iota (PKCi) (Ile375-Val596)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.05% ProClin 300
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Protein Kinase C iota (PKC iota), also known as PRKCI, is an atypical isoform of Protein Kinase C that plays significant roles in cellular signaling. The PKC iota gene is positioned on the human chromosome 3, specifically at 3q26. Its structure is characterized by an absence of the calcium and diacylglycerol regulatory domains that are typically found in conventional PKC isoforms, allowing it to function independently of these signals. PKC iota has been identified as a bona fide oncogene, implicated in various cancers, including lung and ovarian cancers. It is involved in biological processes such as cell differentiation, proliferation, and survival by influencing pathways like NF-?B activation. PKC iota interacts with TRAF6 and IRAK to activate I?B kinase-β, prompting NF-?B to translocate to the nucleus and promote gene expression related to cell survival and growth. Molecular cloning studies have detailed its structure, which is pre-organized before substrate binding, differing considerably from other kinase family members like PKA. PKC iota's critical role in cancer progression and its potential as a prognostic marker make it a key target for therapeutic research, particularly in oncogenic pathways linked to K-Ras mutations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: aPKC-lambda/iota; Atypical protein kinase C-lambda/iota; nPKC-iota; PKC-iota; PRKC-lambda/iota; Protein kinase C iota type; protein kinase C, iota; protein kinase C, lambda
基因别名: 2310021H13Rik; AI427505; aPKClambda; DXS1179E; mKIAA4165; nPKC-iota; PKCI; Pkcl; PKClambda; PRKCI; Prkcl
UniProt ID: (Human) P41743, (Mouse) Q62074, (Rat) F1M7Y5
Entrez Gene ID: (Human) 5584, (Mouse) 18759, (Rat) 84006
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein binding
ATP binding
phospholipid binding
protein domain specific binding
metal ion binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
non-receptor serine/threonine protein kinase
protein phosphorylation
protein targeting to membrane
cytoskeleton organization
actin filament organization
positive regulation of neuron projection development
vesicle-mediated transport
cell migration
peptidyl-serine phosphorylation
cellular response to insulin stimulus
negative regulation of glial cell apoptotic process
establishment of apical/basal cell polarity
intracellular signal transduction
eye photoreceptor cell development
negative regulation of apoptotic process
negative regulation of neuron apoptotic process
establishment or maintenance of epithelial cell apical/basal polarity
cell-cell junction organization
positive regulation of glucose import
secretion
Golgi vesicle budding
positive regulation of NF-kappaB transcription factor activity
positive regulation of glial cell proliferation
membrane organization
response to interleukin-1
bicellular tight junction assembly
positive regulation of establishment of protein localization to plasma membrane
positive regulation of endothelial cell apoptotic process
multicellular organism development
phosphorylation
cellular protein localization
response to peptide hormone
