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Invitrogen
PKN1 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-52036
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.1 mg/mL
规格
10 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.2, with 40% glycerol
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: QKLGLLREAL ERRLGELPAD HPKGRLLREE LAAASSAAFS TRLAGPFPAT HYSTLCKPAP LTGTLEVRVV GCRDLPETIP WNPTPSMGGP GTPDSRPPFL SRPARGLYSR SGSLSGRSSL KAEAENTSEV S
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 86%.
靶标信息
PKN1 (PRK1) belongs to the protein kinase C superfamily. This kinase is activated by the Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can also be activated by phospholipids. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: protease-activated kinase 1; protein kinase C-like 1; protein kinase C-like PKN; protein kinase C-related kinase 1; protein kinase PKN; protein kinase PKN-alpha; protein-kinase C-related kinase 1; serine-threonine kinase N; serine-threonine protein kinase N; serine/threonine kinase; serine/threonine kinase 3; serine/threonine protein kinase N; unnamed protein product
基因别名: DBK; F730027O18Rik; PAK-1; PAK1; PKN; PKN-ALPHA; PRK1; PRKCL1; Stk3
UniProt ID: (Human) Q16512, (Rat) Q63433, (Mouse) P70268
Entrez Gene ID: (Human) 5585, (Rat) 29355, (Mouse) 320795
chromatin binding
transcription coactivator activity
protein kinase activity
protein serine/threonine kinase activity
protein kinase C activity
protein kinase C binding
protein binding
ATP binding
small GTPase binding
histone kinase activity (H3-T11 specific)
histone binding
histone deacetylase binding
androgen receptor binding
protein serine kinase activity
B cell homeostasis
B cell apoptotic process
negative regulation of protein phosphorylation
regulation of germinal center formation
regulation of immunoglobulin production
renal system process
chromatin remodeling
regulation of transcription from RNA polymerase II promoter
protein phosphorylation
negative regulation of protein kinase activity
hyperosmotic response
signal transduction
epithelial cell migration
negative regulation of B cell proliferation
intracellular signal transduction
post-translational protein modification
positive regulation of transcription, DNA-templated
spleen development
regulation of cell motility
regulation of androgen receptor signaling pathway
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