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Invitrogen
PLZF Monoclonal Antibody (6318100), APC
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PLZF Antibody (MA5-23681) in Flow
Flow cytometry of PLZF in HL‚60 human acute promyelocytic leukemia cell line. Samples were incubated in PLZF monoclonal antibody (Product # MA5-23681) or isotype control. To facilitate intracellular staining, cells were fixed with Flow Cytometry Fixation Buffer and permeabilized with Flow Cytometry Permeabilization/Wash Buffer.
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-23681
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
6318100
抗原
E. coli-derived recombinant human PLZF Met1-Gln254
偶联物
APC
APC
APC
激发/发射光谱
651/660 nm
查看光谱
形式
Liquid
纯化类型
Protein A/G
保存液
Buffered saline solution with ≤ 0.5% BSA
内含物
0.09% sodium azide
保存条件
4°C, store in dark, DO NOT FREEZE!
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
In direct ELISAs, no cross-reactivity with recombinant human (rh) ZBTB38, rhZNF24, rhZNF143, rhZNF206, rhZNF281, or rhZNF423 is observed.
靶标信息
This gene is a member of the Krueppel C2H2-type zinc-finger protein family and encodes a zinc finger transcription factor that contains nine Kruppel-type zinc finger domains at the carboxyl terminus. This protein is located in the nucleus, is involved in cell cycle progression, and interacts with a histone deacetylase. Specific instances of aberrant gene rearrangement at this locus have been associated with acute promyelocytic leukemia (APL). Alternate transcriptional splice variants have been characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
How to use the Panel Builder
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生物信息学
蛋白别名: promyelocytic leukaemia zinc finger; zinc finger protein 145 (Kruppel-like, expressed in promyelocytic leukemia); zinc finger protein PLZF
基因别名: PLZF; ZNF145
UniProt ID: (Human) Q05516
Entrez Gene ID: (Human) 7704
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transcription cofactor activity
protein binding
protein domain specific binding
type 2 angiotensin receptor binding
identical protein binding
protein homodimerization activity
negative regulation of transcription from RNA polymerase II promoter
mesonephros development
tolerance induction in gut-associated lymphoid tissue
regulation of transcription from RNA polymerase II promoter
apoptotic process
central nervous system development
regulation of gene expression
protein ubiquitination
hemopoiesis
myeloid cell differentiation
positive regulation of chondrocyte differentiation
protein localization to nucleus
embryonic hindlimb morphogenesis
embryonic digit morphogenesis
ossification involved in bone maturation
regulatory T cell differentiation
regulation of cell differentiation
positive regulation of fat cell differentiation
negative regulation of myeloid cell differentiation
positive regulation of ossification
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NK T cell differentiation
cartilage development
positive regulation of multicellular organismal process
positive regulation of cartilage development
regulation of multicellular organismal development
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