Invitrogen

PMCA ATPase Polyclonal Antibody

1 篇参考文献
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说明书
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说明书
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PMCA ATPase Polyclonal Antibody

产品信息

PA5-107073

应用
建议稀释比
已发表文章

免疫印迹 (WB)

0.2-1 µg/mL
-

免疫细胞化学 (ICC/IF)

-
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产品规格

种属反应

Human

已发表种属

C. elegans

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Synthetic peptide directed towards the middle region of human ATP2B4 (aa 936-985)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Affinity Chromatography

保存液

PBS, pH 7.4, with 2% sucrose

内含物

0.09% sodium azide

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2817789

产品详细信息

Sequence homology: Cow: 93%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%

Immunogen sequence: FAGEKFFDID SGRKAPLHSP PSQHYTIVFN TFVLMQLFNE INSRKIHGEK

靶标信息

The calcium pump of the plasma membrane (PMCA ATPase) pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the sarcoplasmic and endoplasmic reticulum calcium (SERCA) ATPase and the sodium/potassium pump. Studies indicate that there are four known isoforms of the PMCA ATPase which are encoded by a multigene family.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATPase, Ca++ transporting, plasma membrane 1; ATPase, Ca++ transporting, plasma membrane 2; ATPase, Ca++ transporting, plasma membrane 3; ATPase, Ca++ transporting, plasma membrane 4; cilia and flagella associated protein 39; Matrix-remodeling-associated protein 1; plasma membrane Ca(2+)-ATPase; plasma membrane Ca2+ pump 2; plasma membrane calcium ATPase; Plasma membrane calcium ATPase isoform 1; Plasma membrane calcium ATPase isoform 2; Plasma membrane calcium ATPase isoform 3; Plasma membrane calcium ATPase isoform 4; plasma membrane calcium pump; Plasma membrane calcium pump isoform 1; Plasma membrane calcium pump isoform 2; Plasma membrane calcium pump isoform 3; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 1; Plasma membrane calcium-transporting ATPase 2; Plasma membrane calcium-transporting ATPase 3; Plasma membrane calcium-transporting ATPase 4; PMCA1; PMCA2; PMCA3; PMCA4; sarcolemmal calcium pump

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基因别名: ATP2B1; ATP2B2; ATP2B3; ATP2B4; CFAP39; CLA2; MXRA1; OPCA; PMCA1; PMCA1kb; PMCA2; PMCA2a; PMCA2i; PMCA3; PMCA3a; PMCA4; PMCA4b; PMCA4x; SCAX1

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UniProt ID: (Human) P20020, (Human) Q01814, (Human) Q16720, (Human) P23634

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Entrez Gene ID: (Human) 490, (Human) 491, (Human) 492, (Human) 493

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功能
calcium-transporting ATPase activity protein binding calmodulin binding ATP binding PDZ domain binding metal ion binding calcium-dependent ATPase activity sodium channel regulator activity protein phosphatase 2B binding nitric-oxide synthase inhibitor activity nitric-oxide synthase binding scaffold protein binding primary active transporter
参与通路
neural retina development transport cellular calcium ion homeostasis brain development aging response to cold ion transmembrane transport calcium ion transmembrane transport cellular response to vitamin D cellular response to corticosterone stimulus calcium ion export regulation of cardiac conduction calcium ion transport organelle organization lactation sensory perception of sound locomotory behavior regulation of cell size cerebellar Purkinje cell differentiation cerebellar granule cell differentiation neuron differentiation locomotion serotonin metabolic process otolith mineralization cGMP metabolic process regulation of synaptic plasticity synapse organization neuromuscular process controlling balance detection of mechanical stimulus involved in sensory perception of sound regulation of cytosolic calcium ion concentration positive regulation of calcium ion transport auditory receptor cell stereocilium organization cochlea development regulation of transcription from RNA polymerase II promoter spermatogenesis negative regulation of nitric oxide mediated signal transduction hippocampus development sperm motility positive regulation of peptidyl-serine phosphorylation negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity response to hydrostatic pressure negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus calcium ion transmembrane import into cytosol calcium ion import across plasma membrane negative regulation of the force of heart contraction negative regulation of arginine catabolic process negative regulation of adrenergic receptor signaling pathway involved in heart process negative regulation of peptidyl-cysteine S-nitrosylation regulation of sodium ion transmembrane transport regulation of cell cycle G1/S phase transition negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process positive regulation of cAMP-dependent protein kinase activity
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