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Invitrogen
PMS2 Polyclonal Antibody
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PMS2 Antibody (PA5-93306) in WB
Western blot analysis of PMS2 in extracts of various cell lines. Samples were incubated with PMS2 Polyclonal antibody (Product # PA5-93306) using a dilution of 1:2,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
产品信息
PA5-93306
产品规格
种属反应
Human,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PMS2 (NP_0005262)
偶联物
形式
Liquid
浓度
0.85 mg/mL
规格
85 µg
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: Jurkat, A-431, HeLa, Mouse brain, Mouse thymus, Rat brain; Cellular Location: Nucleus
Immunogen sequence: EPAKAIKPID RK
靶标信息
PMS1 protein homologue 2 (PMS2) is a DNA mismatch repair protein. Defects in PMS2 are a cause of hereditary non-polyposis cancer (HNPCC). Human PMS2 is an amino acid protein of 862 amino acids.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DNA mismatch repair protein PMS2; H_DJ0042M02.9; Mismatch repair endonuclease PMS2; PMS1 homolog 2, mismatch repair protein; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2; similar to S. cerevisiae PMS1 Swiss-Prot Accession Number P14242, S. cerevisiae MLH1 GenBank Accession Number U07187, E. coli MUTL Swiss-Prot Accession Number P23367, Salmonella typhimurium MUTL Swiss-Prot Accession Number P14161, Streptococcus pneumoniae ; unnamed protein product
基因别名: HNPCC4; LYNCH4; MLH4; MMRCS4; PMS-2; PMS2; PMS2CL; PMSL2
UniProt ID: (Human) P54278
Entrez Gene ID: (Human) 5395, (Rat) 288479
nucleotide binding
DNA binding
single-stranded DNA binding
nuclease activity
endonuclease activity
protein binding
ATP binding
hydrolase activity
ATPase activity
mismatched DNA binding
single base insertion or deletion binding
MutSalpha complex binding
ATP-dependent DNA damage sensor activity
molecular_function
DNA metabolism protein
DNA repair
mismatch repair
cellular response to DNA damage stimulus
response to xenobiotic stimulus
somatic hypermutation of immunoglobulin genes
somatic recombination of immunoglobulin gene segments
positive regulation of isotype switching to IgA isotypes
positive regulation of isotype switching to IgG isotypes
response to drug
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