Search
Invitrogen
POLB Monoclonal Antibody (18S)
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA5-13899
应用
建议稀释比
已发表文章
产品规格
种属反应
Bovine,
Hamster,
Human,
Mouse,
Rat,
Xenopus
已发表种属
Human,
Mouse,
Rabbit,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
18S
抗原
Rat DNA polymerase beta protein
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.2 mg/mL
规格
100 µg
纯化类型
Protein G
保存液
PBS, pH 7.4, with 0.2% BSA
内含物
0.09% sodium azide
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-13899 targets Rat DNA Polymerase beta in IP and WB applications and shows reactivity with Bovine, Hamster, Human, mouse, Rat, and Xenopus laevis samples.
The MA5-13899 immunogen is rat DNA polymerase beta protein.
靶标信息
DNA polymerase beta comprises an amino-terminal 8- kDa domain and a carboxy-terminal 31- kDa domain. The N-terminal ssDNA binding domain has a deoxyribose phosphodiesterase activity while the C-terminal domain has a nucleotidyltransferase activity. Mammalian DNA polymerase beta, a DNA repair polymerase, is constitutively expressed in cultured cells, but treatment of cells with the DNA-alkylating agents such as N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) or methyl methanesulfonate up-regulates beta-pol level. DNA polymerase beta fills single nucleotide gaps in DNA produced by the base excision repair pathway of mammalian cells.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 5'-deoxyribose-phosphate lyase; 5'-dRP lyase; AP lyase; DNA pol beta; DNA polymerase beta; DNA polymerase beta subunit; DNA-directed DNA polymerase beta; MGC125976; POL B; Pol beta; POLB; polymerase (DNA directed), beta; polymerase (DNA) beta; polymerase B; polymerase beta; polymerase-beta; unnamed protein product
基因别名: A430088C08Rik; polb; XELAEV_18020165mg
UniProt ID: (Human) P06746, (Bovine) Q27958, (Mouse) Q8K409, (Rat) P06766, (Xenopus) O57383
Entrez Gene ID: (Human) 5423, (Bovine) 614688, (Mouse) 18970, (Chinese hamster) 100774965, (Rat) 29240, (Xenopus) 397973
DNA binding
damaged DNA binding
DNA-directed DNA polymerase activity
DNA-(apurinic or apyrimidinic site) lyase activity
protein binding
microtubule binding
nucleotidyltransferase activity
lyase activity
enzyme binding
DNA polymerase activity
metal ion binding
5'-deoxyribose-5-phosphate lyase activity
class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DNA-directed DNA polymerase
DNA-dependent DNA replication
DNA repair
regulation of DNA repair
base-excision repair
base-excision repair, gap-filling
pyrimidine dimer repair
nucleotide-excision repair, DNA gap filling
double-strand break repair via nonhomologous end joining
cellular response to DNA damage stimulus
response to gamma radiation
response to ethanol
response to hyperoxia
DNA biosynthetic process
in utero embryonic development
apoptotic process
inflammatory response
salivary gland morphogenesis
intrinsic apoptotic signaling pathway in response to DNA damage
somatic diversification of immunoglobulins
somatic hypermutation of immunoglobulin genes
lymph node development
spleen development
homeostasis of number of cells
neuron apoptotic process
immunoglobulin heavy chain V-D-J recombination
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
