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Invitrogen
POLG Recombinant Rabbit Monoclonal Antibody (9V9D9)
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POLG Antibody (MA5-37845) in WB
Western blot analysis of POLG in extracts of various cell lines. Samples were incubated with POLG Monoclonal antibody (Product # MA5-37845) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3 min.
产品信息
MA5-37845
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293 cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
9V9D9
抗原
Synthetic peptide
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 0.05% BSA, 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Positive Samples: HT-29, 293T, Mouse testis, Mouse brain, Rat liver, Rat testis
Immunogen sequence: LVREEDRYRA ALALQITNLL TRCMFAYKLG LNDLPQSVAF FSAVDIDRCL RKEVTMDCKT PSNPTGMERR YGIPQGEALD IYQIIELTKG SLEKRSQPGP
靶标信息
Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3'-5' exodeoxyribonuclease; 5'-deoxyribose-phosphate lyase; DNA polymerase gamma; DNA polymerase gamma subunit 1 (Mitochondrial DNA polymerase catalytic subunit) (PolG-alpha); DNA polymerase subunit gamma-1; DNA-directed DNA polymerase gamma; FLJ27114; Mitochondrial DNA polymerase catalytic subunit; mitochondrial DNA polymerase gamma; mitochondrial DNA polymerase gamma catalytic subunit; mitochondrial DNA polymerase-gamma; mitochondrial polymerase gamma; Pol gamma; PolG-alpha; polymerase (DNA directed), gamma; polymerase (DNA) gamma, catalytic subunit; polymerase, gamma; truncated mitochondrial DNA polymerase gamma catalytic subunit
基因别名: AA409516; MDP1; Mip1; MIRAS; MTDPS4A; MTDPS4B; PEO; POLG; POLG1; POLGA; SANDO; SCAE
UniProt ID: (Human) P54098, (Rat) Q9QYV8
Entrez Gene ID: (Human) 5428, (Mouse) 18975, (Rat) 85472
protease binding
DNA binding
chromatin binding
DNA-directed DNA polymerase activity
protein binding
3'-5' exonuclease activity
nucleic acid binding
exonuclease activity
transferase activity
nucleotidyltransferase activity
DNA-directed DNA polymerase
DNA metabolism protein
nucleic acid metabolism protein
DNA metabolic process
DNA-dependent DNA replication
mitochondrial DNA replication
base-excision repair, gap-filling
aging
response to light stimulus
response to gamma radiation
response to hyperoxia
cellular response to glucose stimulus
DNA biosynthetic process
nucleic acid phosphodiester bond hydrolysis
DNA replication
