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Proteintech
POT1 Polyclonal Antibody
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产品信息
10581-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
POT1 Fusion Protein Ag0875 (336-634 aa encoded by BC002923)
偶联物
形式
Liquid
浓度
0.3 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: ILTDHQYLE RTPLCAILKQ KAPQQYRIRA KLRSYKPRRL FQSVKLHCPK CHLLQEVPHE GDLDIIFQDG ATKTPDVKLQ NTSLYDSKIW TTKNQKGRKV AVHFVKNNGI LPLSNECLLL IEGGTLSEIC KLSNKFNSVI PVRSGHEDLE LLDLSAPFLI QGTIHHYGCK QCSSLRSIQN LNSLVDKTSW IPSSVAEALG IVPLQYVFVM TFTLDDGTGV LEAYLMDSDK FFQIPASEVL MDDDLQKSVD MIMDMFCPPG IKIDAYPWLE CFIKSYNVTN GTDNQICYQI FDTTVAEDVI (336-634 aa encoded by BC002923)
靶标信息
POT1 is a component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. It is a component of the double-stranded telomeric DNA-binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase. Pot1 also acts as a single-stranded telomeric DNA-binding protein and thus may act as a downstream effector of the TRF1 complex and may transduce information about telomere maintenance and/or length to the telomere terminus. It binds to two or more telomeric single-stranded 5'-TTAGGG-3' repeats (G-strand) and with high specificity to a minimal telomeric single-stranded 5'-TAGGGTTAG-3' sequence. Its activity is TERT dependent but it does not increase TERT activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: DKFZp586D211; hPot1; mPot1; POT 1; POT-1; POT1-like telomere end-binding protein; protection of telomeres 1 homolog; Protection of telomeres protein 1
基因别名: 1500031H18Rik; AI851169; CMM10; GLM9; HPOT1; POT1; Pot1a
UniProt ID: (Human) Q9NUX5, (Mouse) Q91WC1
Entrez Gene ID: (Human) 25913, (Mouse) 101185
telomere maintenance via telomerase
telomere capping
telomere assembly
positive regulation of telomere maintenance via telomerase
DNA duplex unwinding
positive regulation of helicase activity
positive regulation of telomerase activity
negative regulation of telomerase activity
positive regulation of DNA strand elongation
establishment of protein localization to telomere
telomere maintenance
negative regulation of telomere maintenance via telomerase
chromosome organization
