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Proteintech
PPP2R2B/A/C/D Polyclonal Antibody
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产品信息
29237-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PPP2R2B/A/C/D fusion protein Ag30757
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.6 mg/mL
规格
90 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: SHSGRYIMTR DYLTVKVWDL NMENRPIETY QVHDYLRSKL CSLYENDCIF DKFECVWNGS DSVIMTGSYN NFFRMFDRNT KRDVTLEASR ENSKPRAILK PRKVCVGGKR RKDEISVDSL DFSKKILHTA WHPSENIIAV AATNNLYIFQ DKVN
靶标信息
The genes PPP2R2B, PPP2R2A, PPP2R2C, and PPP2R2D encode different regulatory subunits of protein phosphatase 2 (PP2A), a major serine/threonine phosphatase implicated in various cellular processes. PPP2R2B is located on chromosome 5q32 and has multiple alternatively spliced transcripts, playing a significant role in cancer prognosis and immune evasion (ScienceDirect). PPP2R2A, encoding the B55 alpha subunit, is frequently deleted in prostate adenocarcinomas, correlating with poor prognosis (PubMed). PPP2R2C, encoding the B55 gamma isoform, is shown to suppress glioma cell proliferation, acting as a tumor suppressor (ScienceDirect). PPP2R2D is involved in T-cell regulation and cancer cell proliferation, with overexpression linked to increased mTOR activity and impact on IL-2 production (PubMed). Collectively, these genes highlight the complexity and critical regulatory roles of PP2A subunits in cell signaling and disease pathology.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: B55; BRbeta B-regulatory subunit of protein phosphatase 2A; IMYPNO1; phosphoprotein phosphatase 2A BR gamma regulatory chain; PP2A subunit B isoform alpha; PP2A subunit B isoform B55-alpha; PP2A subunit B isoform B55-beta; PP2A subunit B isoform B55-delta; PP2A subunit B isoform B55-gamma; PP2A subunit B isoform beta; PP2A subunit B isoform BRA; PP2A subunit B isoform BRB; PP2A subunit B isoform BRgamma; PP2A subunit B isoform delta; PP2A subunit B isoform gamma; PP2A subunit B isoform PR55-alpha; PP2A subunit B isoform PR55-beta; PP2A subunit B isoform PR55-delta; PP2A subunit B isoform PR55-gamma; PP2A subunit B isoform R2-alpha; PP2A subunit B isoform R2-beta; PP2A subunit B isoform R2-delta; PP2A subunit B isoform R2-gamma; PP2A, subunit B, B-alpha isoform; PP2A, subunit B, B-beta isoform; PP2A, subunit B, B-delta isoform; PP2A, subunit B, B-gamma isoform; PP2A, subunit B, B55-alpha isoform; PP2A, subunit B, B55-beta isoform; PP2A, subunit B, B55-delta isoform; PP2A, subunit B, B55-gamma isoform; PP2A, subunit B, BRA isoform; PP2A, subunit B, BRB isoform; PP2A, subunit B, BRgamma isoform; PP2A, subunit B, PR55-alpha isoform; PP2A, subunit B, PR55-beta isoform; PP2A, subunit B, PR55-delta isoform; PP2A, subunit B, PR55-gamma isoform; PP2A, subunit B, R2-alpha isoform; PP2A, subunit B, R2-beta isoform; PP2A, subunit B, R2-delta isoform; PP2A, subunit B, R2-gamma isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform; protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform; protein phosphatase 2 regulatory subunit B, delta; protein phosphatase 2, regulatory subunit B, alpha; protein phosphatase 2, regulatory subunit B, beta; protein phosphatase 2, regulatory subunit B, delta isoform; protein phosphatase 2A B regulatory subunit delta isoform; protein phosphatase 2A, regulatory subunit B, delta isoform; protein phosphatase 2A1 B gamma subunit; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform; Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform; unnamed protein product; upstream ORF 1; upstream ORF 2
基因别名: 1300017E19Rik; 2410004D02Rik; 2900026H06Rik; 6330404L05Rik; 6330548O06Rik; B55; B55-GAMMA; B55A; B55ALPHA; B55BETA; B55D; B55delta; B55gamma; D7Ertd753e; E130009M08Rik; IMYPNO; IMYPNO1; KIAA1541; MDS026; mKIAA1541; PP2A-PR55B; PP2AB55BETA; PP2ABBETA; PP2APR55B; PP2APR55BETA; PPP2R2A; PPP2R2B; PPP2R2C; PPP2R2D; Pppr2b2; PR2AB55BETA; PR2ABBETA; PR2APR55BETA; PR52; PR52A; PR52B; PR55-BETA; PR55A; PR55alpha; PR55BETA; PR55G; SCA12
UniProt ID: (Human) P63151, (Human) Q00005, (Human) Q9Y2T4, (Human) Q66LE6, (Mouse) Q6P1F6, (Rat) P36876, (Rat) P36877, (Mouse) Q6ZWR4, (Mouse) Q8BG02, (Rat) P97888, (Rat) P56932, (Mouse) Q925E7
Entrez Gene ID: (Human) 5520, (Human) 5521, (Human) 5522, (Human) 55844, (Mouse) 71978, (Rat) 117104, (Rat) 60660, (Mouse) 72930, (Mouse) 269643, (Rat) 117256, (Rat) 246255, (Mouse) 52432
protein binding
protein phosphatase regulator activity
macromolecular complex binding
tau protein binding
protein phosphatase 2A binding
enzyme-substrate adaptor activity
protein serine/threonine phosphatase activity
protein phosphatase type 2A regulator activity
protein complex binding
phosphatidate phosphatase activity
protein phosphatase
protein dephosphorylation
response to morphine
regulation of chromosome segregation
apoptotic process
mitotic cell cycle
exit from mitosis
cell division
signal transduction
regulation of catalytic activity
mitochondrial fission
protein targeting to mitochondrion
spermatid development
brain development
neuron differentiation
regulation of protein phosphatase type 2A activity
positive regulation of neuron apoptotic process
mitochondrial fragmentation involved in apoptotic process
mitotic nuclear division
dephosphorylation
cell cycle
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