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Invitrogen
PRAK Polyclonal Antibody
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产品信息
PA5-21880
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human PRAK. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.62 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 10% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: 293T, A431, H1299, HeLaS3, HepG2, Molt-4, Raji.
Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (83%), Pig (97%), Chicken (95%), Rhesus Monkey (99%), Bovine (96%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
MAPKAPK5 (PRAK) is activated in response to cellular stress and pro-inflammatory cytokines. Activity of this kinase is regulated by p38 alpha and p38 beta. The protein encoded by PRAK is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of PRAK encoding distinct isoforms have been reported.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAPK-5; p38-regulated/activated protein kinase; PRAK
基因别名: MAPKAP-K5; MAPKAPK5; MK-5; MK5; PRAK
UniProt ID: (Human) Q8IW41
Entrez Gene ID: (Human) 8550
MAPK cascade
activation of MAPK activity
regulation of translation
signal transduction
Ras protein signal transduction
peptidyl-serine phosphorylation
negative regulation of TOR signaling
positive regulation of telomere maintenance via telomerase
protein autophosphorylation
positive regulation of telomerase activity
stress-induced premature senescence
regulation of signal transduction by p53 class mediator
positive regulation of telomere capping
