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Invitrogen
PRKAR2A Monoclonal Antibody (H2 006 D4)
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产品信息
MA3-517
产品规格
已发表种属
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
H2 006 D4
抗原
Column purified fraction of cAMP dependent PKA RII from human saliva.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Wet ice
RRID
产品详细信息
MA3-517 detects PKA RII protein in human samples. MA3-517 does not discriminate between RII alpha and beta.
MA3-517 has successfully been used in Western blot procedures. By Western blot, this antibody detects an ~50 kDa protein representing PKA RII in human saliva.
MA3-517 has successfully been used in ChIP analysis of PKARII.
The MA3-517 immunogen is a purified fraction of cAMP dependent PKA RII from human saliva.
靶标信息
cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase (AMPK), which transduces the signal through phosphorylation of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits of AMPK have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of AMPK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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