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Invitrogen
PRMT2 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-142908
产品规格
种属反应
Human,
Mouse,
Pig,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Peptide with sequence C-DQPRTTKYHSVILQ.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Additional Information: This antibody is expected to recognize all reported isoforms (NP_001526.2; NP_001229793.1; NP_001229794.1; NP_001229795.1).
This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.
靶标信息
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: heterogeneous nuclear ribonucleoprotein methyltransferase-like 1; histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1; HMT1 hnRNP methyltransferase-like 1; HRMT1L1; MGC111373; PRMT2 alpha; PRMT2 beta; PRMT2 gamma; unnamed protein product
基因别名: HRMT1L1
UniProt ID: (Human) P55345
Entrez Gene ID: (Pig) 100294709, (Human) 3275, (Rat) 499420, (Mouse) 15468
transcription coactivator activity
protein binding
methyltransferase activity
protein-arginine N-methyltransferase activity
estrogen receptor binding
progesterone receptor binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
protein homodimerization activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
macromolecular complex binding
thyroid hormone receptor binding
androgen receptor binding
histone H3R8 methyltransferase activity
histone H3 methyltransferase activity
beta-catenin binding
protein modifying enzyme
chromatin remodeling
regulation of transcription, DNA-templated
negative regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription, DNA-templated
negative regulation of inflammatory response
regulation of androgen receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
response to hypoxia
JAK-STAT cascade
biological_process
negative regulation of transcription, DNA-templated
methylation
leptin-mediated signaling pathway
positive regulation of apoptotic process
receptor signaling pathway via STAT
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