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Proteintech
PRMT2 Monoclonal Antibody (1F1B9), CoraLite® 594
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产品信息
CL594-66885
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG2a
分类
Monoclonal
类型
Antibody
克隆号
1F1B9
抗原
Recombinant protein
偶联物
激发/发射光谱
593/614 nm
形式
Liquid
纯化类型
Protein A
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: ESLTDKVILD VGCGTGIISL FCAHYARPRA VYAVEASEMA QHTGQLVLQN GFADIITVYQ QKVEDVVLPE KVDVLVSEWM GTCLLFEFMI ESILYARDAW LKEDGVIWPT MAALHLVPCS ADKDYRSKVL FWDNAYEFNL SALKSLAVKE FFSKPKYNHI LKPEDCLSEP CTILQLDMRT VQISDLETLR GELRFDIRKA GTLHGFTAWF SVHFQSLQEG QPPQVLSTGP FHPTTHWKQT LFMMDDPVPV HTGDVVTGSV VLQRNPVWIR HMSVALSWAV TSRQDPTSQK VGEKVFPIWR
靶标信息
Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). May be involved in growth regulation. [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Histone-arginine N-methyltransferase PRMT2; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1; HMT1 hnRNP methyltransferase-like 1; MGC111373; PRMT2 alpha; PRMT2 beta; PRMT2 gamma; Protein arginine N-methyltransferase 2
基因别名: AI504737; HMT1; HRMT1L1; PRMT2
UniProt ID: (Human) P55345
Entrez Gene ID: (Human) 3275, (Mouse) 15468, (Rat) 499420
transcription coactivator activity
signal transducer activity
protein binding
histone-arginine N-methyltransferase activity
protein-arginine N-methyltransferase activity
estrogen receptor binding
progesterone receptor binding
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
protein homodimerization activity
retinoic acid receptor binding
peroxisome proliferator activated receptor binding
thyroid hormone receptor binding
androgen receptor binding
molecular_function
cytokine activity
tumor necrosis factor receptor binding
beta-catenin binding
protein modifying enzyme
protein methylation
signal transduction
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
negative regulation of NF-kappaB transcription factor activity
histone arginine methylation
positive regulation of apoptotic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
developmental cell growth
regulation of androgen receptor signaling pathway
negative regulation of G1/S transition of mitotic cell cycle
response to hypoxia
immune response
biological_process
peptidyl-arginine N-methylation
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of extrinsic apoptotic signaling pathway
