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Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the suprachiasmatic nucleus (SCN) with receptors located in the critical autonomic control centers of the brain. It has a depolarizing effect on neurons expressing the receptor. PK2 is predominantly controlled by the endogenous circadian clock, but light also plays a modulatory role. PK2 functions as a critical SCN output molecule responsible for circadian locomotor rhythms. PK2 expression is high during the day, and responsive to nocturnal light pulses. PK2 also functions as a chemoattractant for subventricular zone-derived neuronal progenitors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Bombina variegata 8 kD protein; Bombina variegata 8kDa protein; Bv 8 homolog (Bombina variegata); PK2; prokineticin 1; Prokineticin-2; Protein Bv8 homolog
基因别名: Bv8; PK2; Prok1; Prok2
UniProt ID: (Mouse) Q9QXU7
Entrez Gene ID: (Mouse) 50501