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QED Bioscience
PSE1/Ku Protein Monoclonal Antibody (N3H10)
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产品信息
70104-200UG
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2b
分类
Monoclonal
类型
Antibody
克隆号
N3H10
抗原
Proximal sequence element (PSE1) of the human U1 small nuclear RNA extracted from human placenta.
偶联物
形式
Liquid
浓度
0.5-1.0 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J rUniProtKB:P12956, PubMed:12145306}.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 86 kDa subunit of Ku antigen; ATP-dependent DNA helicase 2 subunit 2; ATP-dependent DNA helicase II 80 kDa subunit; CTC box-binding factor 85 kDa subunit; CTC85; CTCBF; DNA repair protein XRCC5; Imp5; importin beta-3 subunit; Importin subunit beta-3; Importin-5; karyopherin (importin) beta 3; Karyopherin beta-3; Ku autoantigen, 80kDa; Ku80; Ku86; Ku86 autoantigen related protein 1; Lupus Ku autoantigen protein p86; Nuclear factor IV; RAN binding protein 5; Ran-binding protein 5; Ran_GTP binding protein 5; RanBP5; Thyroid-lupus autoantigen; TLAA; X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); X-ray repair cross-complementing protein 5
基因别名: G22P2; IMB3; imp5; IPO5; KARP-1; KARP1; KPNB3; KU80; Ku86; KUB2; NFIV; Pse1; RANBP5; XRCC5
UniProt ID: (Human) O00410, (Human) Q53HH7
Entrez Gene ID: (Human) 3843, (Human) 7520
GTPase inhibitor activity
protein binding
nuclear localization sequence binding
Ran GTPase binding
protein transporter activity
poly(A) RNA binding
DNA binding
damaged DNA binding
double-stranded DNA binding
double-stranded telomeric DNA binding
ATP-dependent DNA helicase activity
ATP binding
protein C-terminus binding
ubiquitin protein ligase binding
telomeric DNA binding
transcription regulatory region DNA binding
macromolecular complex binding
5'-deoxyribose-5-phosphate lyase activity
DNA helicase
transporter
protein import into nucleus, docking
protein import into nucleus, translocation
NLS-bearing protein import into nucleus
ribosomal protein import into nucleus
viral process
negative regulation of GTPase activity
positive regulation of protein import into nucleus
cellular response to amino acid stimulus
telomere maintenance
double-strand break repair
double-strand break repair via nonhomologous end joining
DNA recombination
transcription, DNA-templated
cell proliferation
positive regulation of type I interferon production
DNA duplex unwinding
negative regulation of transcription, DNA-templated
regulation of smooth muscle cell proliferation
positive regulation of neurogenesis
hematopoietic stem cell differentiation
cellular response to gamma radiation
cellular response to X-ray
establishment of integrated proviral latency
negative regulation of t-circle formation
