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Invitrogen
PSMC1 Polyclonal Antibody
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PSMC1 Antibody (PA5-90640) in WB
Western blot analysis of PSMC1 in extracts of various cell lines. Samples were incubated with PSMC1 Polyclonal antibody (Product # PA5-90640) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
产品信息
PA5-90640
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 77-440 of human PSMC1 (NP_0027932)
偶联物
形式
Liquid
浓度
0.77 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: EFIRNQEQMK PLEEKQEEER SKVDDLRGTP MSVGTLEEII DDNHAIVSTS VGSEHYVSIL SFVDKDLLEP GCSVLLNHKV HAVIGVLMDD TDPLVTVMKV EKAPQETYAD IGGLDNQIQE IKESVELPLT HPEYYEEMGI KPPKGVILYG PPGTGKTLLA KAVANQTSAT FLRVVGSELI QKYLGDGPKL VRELFRVAEE HAPSIVFIDE IDAIGTKRYD SNSGGEREIQ RTMLELLNQL DGFDSRGDVK VIMATNRIET LDPALIRPGR IDRKIEFPLP DEKTKKRIFQ IHTSRMTLAD DVTLDDLIMA KDDLSGADIK AICTEAGLMA LRERRMKVTN EDFKKSKENV LYKKQEGTPE GLYL; Positive Samples: A-549, DU145, Jurkat, HeLa, Mouse brain, Mouse heart, Mouse kidnay, Rat liver; Cellular Location: Cytoplasm, Lipid-anchor, Membrane, Nucleus
靶标信息
The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; MGC24583; MGC8541; P26s4; peptidase (prosome, macropain) 26S subunit, ATPase 1; protease (prosome, macropain) 26S subunit, ATPase 1; proteasome (prosome, macropain) 26S subunit, ATPase, 1; proteasome 26S ATPase subunit 1; Proteasome 26S subunit ATPase 1; proteasome 26S subunit, ATPase, 1; prs4
基因别名: AI325227; P26S4; p56; PSMC1; rpt2; Rpt2/S4; S4
UniProt ID: (Human) P62191, (Rat) P62193, (Mouse) P62192
Entrez Gene ID: (Human) 5700, (Rat) 117263, (Mouse) 19179
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
ER-associated ubiquitin-dependent protein catabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
negative regulation of neuron death
positive regulation of proteasomal protein catabolic process
biological_process
protein catabolic process
