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Invitrogen
PSMC3IP Polyclonal Antibody
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PSMC3IP Antibody (PA5-60712)
Relative expression in different tissues in IHC: Detection of differential expression levels of PSMC3IP demonstrates antibody specificity. Immunohistochemical analysis of PSMC3IP using anti-PSMC3IP Polyclonal Antibody (Product # PA5-60712), shows significant staining of PSMC3IP in human testis and shows minimal or weak staining in human liver tissues. The relative expression levels of PSMC3IP within each t... View More
产品信息
PA5-60712
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein corresponding to Human PSMC3IP
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
Immunogen sequence: PEEKEQVYRE RQKYCKEWRK RKRMATELSD AILEGYPKSK KQFFEEVGIE TDEDYNVTLP D
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 93%.
靶标信息
PSMC3IP plays an important role in meiotic recombination. It stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. It may inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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