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Proteintech
PSMD11 Polyclonal Antibody
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产品信息
14786-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PSMD11 Fusion Protein Ag6435 (76-422 aa encoded by BC000437)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: FLNSISKAK AARLVRSLLD LFLDMEAATG QEVELCLECI EWAKSEKRTF LRQALEARLV SLYFDTKRYQ EALHLGSQLL RELKKMDDKA LLVEVQLLES KTYHALSNLP KARAALTSAR TTANAIYCPP KLQATLDMQS GIIHAAEEKD WKTAYSYFYE AFEGYDSIDS PKAITSLKYM LLCKIMLNTP EDVQALVSGK LALRYAGRQT EALKCVAQAS KNRSLADFEK ALTDYRAELR DDPIISTHLA KLYDNLLEQN LIRVIEPFSR VQIEHISSLI KLSKADVERK LSQMILDKKF HGILDQGEGV LIIFDEPPVD KTYEAALETI QNMSKVVDSL YNKAKKLT (76-422 aa encoded by BC000437 )
靶标信息
The 26S proteasome (PSMD11) is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The protein is a non-ATPase subunit of the 19S regulator.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 26S proteasome non-ATPase regulatory subunit 11; 26S proteasome regulatory subunit 9; 26S proteasome regulatory subunit p44.5; 26S proteasome regulatory subunit RPN6; 26S proteasome regulatory subunit S9; proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
基因别名: 1700089D09Rik; 1810019E17Rik; 2610024G20Rik; 2810055C24Rik; C78232; P44.5; PSMD11; Rpn6; S9
UniProt ID: (Human) O00231, (Mouse) Q8BG32
Entrez Gene ID: (Human) 5717, (Rat) 303353, (Mouse) 69077
ubiquitin-dependent protein catabolic process
proteasome assembly
stem cell differentiation
MAPK cascade
protein polyubiquitination
stimulatory C-type lectin receptor signaling pathway
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
regulation of cellular amino acid metabolic process
anaphase-promoting complex-dependent catabolic process
tumor necrosis factor-mediated signaling pathway
NIK/NF-kappaB signaling
Fc-epsilon receptor signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of mRNA stability
T cell receptor signaling pathway
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
Wnt signaling pathway, planar cell polarity pathway
negative regulation of canonical Wnt signaling pathway
positive regulation of canonical Wnt signaling pathway
