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Abnova
PTPN11 Polyclonal Antibody, MaxPab™
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产品信息
H00005781-D01P
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PTPN11 (AAH08692.1, 1 a.a. approximately 460 a.a) full-length human protein.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5-1 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF RTWPDHGVPS DPGGVLDFLE EVHHKQESIM DAGPVVVHCR
靶标信息
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 2SH2 domain protein; HCP; HGNC:9644; MGC14433; Mutations: 351:OK; Noonan syndrome 1; OTTHUMP00000166108; Protein-tyrosine phosphatase 1D; Protein-tyrosine phosphatase 2C; PTP-1D; PTP-2C; PTP1C; SH-PTP2; SH-PTP3; SH2 domain-containing protein tyrosine phosphatase 2; SHP-2; Tyrosine-protein phosphatase non-receptor type 11; unnamed protein product
基因别名: BPTP3; CFC; JMML; METCDS; NS1; PTP-1D; PTP2C; PTPN11; SH-PTP2; SH-PTP3; SHP2; SHPTP2
UniProt ID: (Human) Q06124
Entrez Gene ID: (Human) 5781
phosphotyrosine binding
phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
insulin receptor binding
protein binding
hydrolase activity
protein kinase binding
receptor signaling complex scaffold activity
receptor tyrosine kinase binding
cadherin binding
cell adhesion molecule binding
peptide hormone receptor binding
binding, bridging
protein tyrosine kinase binding
DNA damage checkpoint
neutrophil activation involved in immune response
lipid metabolic process
triglyceride metabolic process
signal transduction
epidermal growth factor receptor signaling pathway
integrin-mediated signaling pathway
axonogenesis
brain development
heart development
fibroblast growth factor receptor signaling pathway
hormone-mediated signaling pathway
positive regulation of signal transduction
cytokine-mediated signaling pathway
cerebellar cortex formation
platelet formation
T cell costimulation
positive regulation of lipopolysaccharide-mediated signaling pathway
negative regulation of chondrocyte differentiation
negative regulation of type I interferon production
positive regulation of type I interferon production
microvillus organization
positive regulation of interferon-beta production
positive regulation of tumor necrosis factor production
regulation of cell adhesion mediated by integrin
negative regulation of cell adhesion mediated by integrin
multicellular organism growth
organ growth
peptidyl-tyrosine dephosphorylation
megakaryocyte development
atrioventricular canal development
ERBB signaling pathway
negative regulation of T cell proliferation
vasodilation
hormone metabolic process
glucose homeostasis
regulation of protein complex assembly
regulation of MAPK cascade
positive regulation of ossification
positive regulation of mitotic cell cycle
positive regulation of glucose import
positive regulation of insulin receptor signaling pathway
negative regulation of insulin secretion
regulation of protein export from nucleus
positive regulation of hormone secretion
negative regulation of hormone secretion
platelet-derived growth factor receptor signaling pathway
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
genitalia development
inner ear development
homeostasis of number of cells within a tissue
negative regulation of cortisol secretion
positive regulation of protein kinase B signaling
Bergmann glial cell differentiation
negative regulation of growth hormone secretion
face morphogenesis
regulation of type I interferon-mediated signaling pathway
intestinal epithelial cell migration
positive regulation of ERK1 and ERK2 cascade
cellular response to mechanical stimulus
cellular response to epidermal growth factor stimulus
positive regulation of intracellular signal transduction
negative regulation of neutrophil activation
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