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Invitrogen
PTPN13 Polyclonal Antibody
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产品信息
PA1-29044
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fragment, corresponding to amino acids 2290-2491 of Human PTPN13
偶联物
形式
Liquid
保存条件
4°C, do not freeze
运输条件
Wet ice
产品详细信息
PA1-29044 detects PTPN13 from human samples.
PA1-29044 has been successfully used in immunohistochemistry (paraffin tissue) applications.
The PA1-29044 immunogen is: Recombinant fragment, corresponding to amino acids 2290-2491 of Human PTPN13
靶标信息
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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