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Proteintech
PURB Polyclonal Antibody
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产品信息
18128-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
PURB Fusion Protein Ag12705 (1-312 aa encoded by BC101735)
偶联物
形式
Liquid
浓度
0.16 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MADGDSGSE RGGGGGPCGF QPASRGGGEQ ETQELASKRL DIQNKRFYLD VKQNAKGRFL KIAEVGAGGS KSRLTLSMAV AAEFRDSLGD FIEHYAQLGP SSPEQLAAGA EEGGGPRRAL KSEFLVRENR KYYLDLKENQ RGRFLRIRQT VNRGGGGFGA GPGPGGLQSG QTIALPAQGL IEFRDALAKL IDDYGGEDDE LAGGPGGGAG GPGGGLYGEL PEGTSITVDS KRFFFDVGCN KYGVFLRVSE VKPSYRNAIT VPFKAWGKFG GAFCRYADEM KEIQERQRDK LYERRGGGSG GGEESEGEEV DED (1-312 aa encoded by BC101735)
靶标信息
This gene product is a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: PurB beta; purine-rich element binding protein B; Purine-rich element-binding protein B; purine-rich single-stranded DNA-binding protein beta; transcription factor Pur-beta; transcriptional activator protein Pur-beta; Transcriptional regulator protein Pur-beta; Vascular actin single-stranded DNA-binding factor 2 p44 component
基因别名: 2310015K15Rik; AA114818; Cager-2; D11Bwg0414e; pur-beta; PURB; PURBETA
UniProt ID: (Human) Q96QR8, (Mouse) O35295, (Rat) Q68A21
Entrez Gene ID: (Human) 5814, (Mouse) 19291, (Rat) 498407
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
single-stranded DNA binding
mRNA binding
transcription factor binding
poly(A) RNA binding
SMAD binding
translation repressor activity, nucleic acid binding
DNA binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
RNA binding
protein binding
purine-rich negative regulatory element binding
DNA-binding transcription factor
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
cell proliferation
cell differentiation
regulation of myeloid cell differentiation
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
negative regulation of translation
negative regulation of transcription, DNA-templated
