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Proteintech
PXR Monoclonal Antibody (1G3A7), CoraLite® Plus 488
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产品信息
CL488-67912
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
1G3A7
抗原
Recombinant protein
偶联物
激发/发射光谱
493/522 nm
形式
Liquid
纯化类型
Protein G
保存液
PBS with 50% glycerol, 0.5% BSA
内含物
0.05% ProClin 300
保存条件
-20°C, store in dark
运输条件
Wet ice
产品详细信息
Immunogen sequence: MTCEGCKGFF RRAMKRNARL RCPFRKGACE ITRKTRRQCQ ACRLRKCLES GMKKEMIMSD EAVEERRALI KRKKSERTGT QPLGVQGLTE EQRMMIRELM DAQMKTFDTT FSHFKNFRPG VLSSGCELPE SLQAPSREEA AKWSQVRKDL CSLKVSLQLR GEDGSVWNYK PPADSGGKEI FSLLPHMADM STYMFKGIIS FAKVISYFRD LPIEDQISLL KGAAFELCQL RFNTVFNAET GTWECGRLSY CLEDTAGGFQ QLLLEPMLKF HYMLKKLQLH EEEYVLMQAI SLFSPDRPGV LQHRVVDQLQ EQFAITLKSY IECNRPQPAH RFLFLKIMAM LTELRSINAQ HTQRLLRIQD IHPFATPLMQ ELFGITGS
靶标信息
This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Nuclear receptor subfamily 1 group I member 2; nuclear receptor subfamily 1, group 1, member 2; nuclear receptor subfamily 1, group I, member 2; ONR 1; Orphan nuclear receptor PAR1; Orphan nuclear receptor PXR; PAR 1; PAR 2; PAR q; pregnane X nuclear receptor variant 2; Pregnane X receptor; pregnane X receptor (nuclear receptor sub family 1, group I, member 2); Steroid and xenobiotic receptor; SXR
基因别名: BXR; mPXR; NR1I2; ONR1; PAR; PAR1; PAR2; PARq; PRR; PXR; PXR.1; PXR.2; PXR1; SAR; SXR
UniProt ID: (Human) Q9UJ22, (Rat) Q9R1A7, (Mouse) O54915
Entrez Gene ID: (Human) 8856, (Rat) 84385, (Mouse) 18171
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
steroid hormone receptor activity
transcription coactivator activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
drug binding
zinc ion binding
DNA binding
transcription factor activity, sequence-specific DNA binding
sequence-specific DNA binding
metal ion binding
transcription, DNA-templated
xenobiotic metabolic process
positive regulation of gene expression
intracellular receptor signaling pathway
exogenous drug catabolic process
xenobiotic transport
steroid hormone mediated signaling pathway
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
drug export
transcription initiation from RNA polymerase II promoter
signal transduction
steroid metabolic process
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
