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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Antibody detects endogenous levels of total ASC2.
ASC2 associates with PYCARD/ASC and modulates its ability to collaborate with MEFV/pyrin and NLRP3/cryopyrin in NF-kappa-B and pro-caspase-1 activation. It suppresses kinase activity of NF-kappa-B inhibitor kinase (IKK) complex, expression of NF-kappa-B inducible genes and inhibits NF-kappa-B activation by cytokines and LPS.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: cellular POP1; cPOP1; PAAD-only protein 1; Pyrin domain-containing protein 1; Pyrin-only protein 1
基因别名: ASC2; ASCI; POP1; PYC1; PYDC1
Entrez Gene ID: (Human) 260434