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Invitrogen
PYROXD1 Polyclonal Antibody
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PYROXD1 Antibody (PA5-114404) in IHC (P)
Immunohistochemistry analysis of PYROXD1 in paraffin-embedded human mammary cancer tissues. Antigen retrieval was performed with citrate buffer (pH6, 20 min). Samples were blocked with 10% goat serum and incubated in PYROXD1 polyclonal antibody (Product # PA5-114404) at a dilution of 1 µg/mL (overnight, 4°C), followed by biotinylated goat anti-rabbit IgG (30 min, 37°C) and Strepavidin-Biotin-Complex (SABC) ... View More
产品信息
PA5-114404
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
E.coli-derived human PYROXD1 recombinant protein (Position: K48-N230).
偶联物
形式
Lyophilized
浓度
500 µg/mL
纯化类型
Affinity chromatography
保存液
PBS with 4mg trehalose
内含物
0.05mg sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Positive Control - WB: human placenta tissue, human U-87MG whole cell, human HL-60 whole cell, human THP-1 whole cell, human PC-3 whole cell, rat kidney tissue. IHC: human mammary cancer tissue, human colon cancer tissue, human lung cancer tissue, mouse intestine tissue, rat intestine tissue.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
靶标信息
The PYROXD1 gene encodes the protein pyridine nucleotide-disulphide oxidoreductase domain 1, which has a significant role in mitochondrial function and cellular redox homeostasis. This gene is involved in maintaining the balance of oxidative stress within cells and is crucial for the redox regulation of cellular components, impacting processes like energy metabolism and apoptosis. Mutations in PYROXD1 have been associated with early-onset myopathy, indicating its importance in muscle development and maintenance. The protein encoded by PYROXD1 is part of the oxidoreductase enzyme family that facilitates electron transfer, contributing to cellular defense against oxidative damage. Recent studies have linked PYROXD1 to various neuromuscular disorders, where disruptions in its function affect muscle fiber alignment and force production. Understanding its role in redox biology is crucial for developing therapeutic strategies to combat muscle pathologies and redox-related diseases.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: FLJ22028; Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1
基因别名: PYROXD1
UniProt ID: (Human) Q8WU10, (Rat) Q68FS6, (Mouse) Q3TMV7
Entrez Gene ID: (Human) 79912, (Rat) 297708, (Mouse) 232491
