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Invitrogen
Perlecan Monoclonal Antibody (A7L6)
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Perlecan Antibody (MA5-14641) in IHC (P)
Immunohistochemistry analysis of Perlecan showing staining in the cytoplasm (Basement membrane cell) of paraffin-embedded human kidney tissue (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15... View More
产品信息
MA5-14641
应用
建议稀释比
已发表文章
产品规格
已发表种属
Bovine,
C. elegans,
Human,
Mouse
宿主/亚型
Rat
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
A7L6
抗原
Murine EHS laminin preparation
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-14641 targets Perlecan in IF, IHC (F), and IHC (P, F) applications and shows reactivity with Bovine, Human, mouse, and Porcine samples.
The MA5-14641 immunogen is mouse EHS laminin preparation.
靶标信息
Perlecan is a major heparan-sulfate proteoglycan (HSPG) found within all basement membranes and cell surfaces. Because of its strategic location and ability to store and protect growth factors, perlecan has been strongly implicated in the control of tumor cell growth and metastatic behavior. Perlecan possesses angiogenic and growth-promoting attributes primarily by acting as a coreceptor for basic fibroblast growth factor (FGF-2). Suppression of perlecan causes substantial inhibition of neoplastic growth and neovascularization. Thus, perlecan is a potent inducer of neoplasm growth and angiogenesis in vivo and therapeutic interventions targeting this key modulator of tumor progression may improve neoplastic treatment.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
