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Invitrogen
Phospho-Amyloid Precursor Protein (Thr729) Polyclonal Antibody
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产品信息
PA5-64814
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide around phosphorylation site of threonine 729 derived from human Amyloid Precursor Protein (APP)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
Phospho-beta Amyloid (Thr729) Polyclonal Antibody detects endogenous levels of beta Amyloid only when phosphorylated at Thr729.
靶标信息
Amyloid Precursor Protein (APP) or Amyloid beta precursor protein functions as a cell surface kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. APP is important for neurite growth, neuronal adhesion and axonogenesis. APP is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms resulting from alternative splicing. Proteolytic cleavage of APP by beta- and gamma-secretases results in the generation of beta amyloid, which is the primary component of senile plaques. Senile plaques are one of the major histopathologic features of Alzheimer's disease. Abnormal regulation and processing of APP also plays a role in Down's syndrome, early onset familial Alzheimer's disease, and cerebral hemorrhage.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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