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Invitrogen
Phospho-Aquaporin 2 (Ser256) Polyclonal Antibody
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产品信息
PA5-38407
产品规格
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human Aquaporin 2 around the phosphorylation site of Ser256 (R-Q-SP-V-E)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
PA5-38407 has been used successfully in peptide-ELISA at a dilution of 1:40,000.
靶标信息
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
