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Invitrogen
Phospho-Beclin 1 (Ser234) Polyclonal Antibody
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Phospho-Beclin 1 (Ser234) Antibody (PA5-35393) in WB
Western blot of Beclin 1 in wild type beclin-1 expressed in HeLa cell lysate showing specific immunolabeling of Phospho-Beclin 1 (Ser234) polyclonal antibody (Product # PA5-35393). This immunolabeling is decreased in the beclin-1 double alanine substitution mutant (S234A, S295A).
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-35393
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser234 of human BECN1 conjugated to KLH
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
~0.3 mg/mL
纯化类型
Affinity chromatography
保存液
0.01M HEPES, pH 7.5, with 0.15M NaCl, 0.1mg/mL BSA, 50% glycerol
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, non-human primate, rat and sheep based on 100% sequence homology.
In Western blot, additional bands may be observed when using non-immunoprecipitated lysates.
靶标信息
Beclin 1 plays a central role in autophagy. It acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate. Different PI3K complex forms are believed to play a role in multiple membrane trafficking pathways - PI3KC3-C1 is involved in the initation of autophagosomes and PI3KC3-C2 is involved in the maturation of autophagosomes and endocytosis. Beclin 1 also plays a role in antiviral host defense.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: APG6; ATG6 autophagy related 6 homolog; Bcl-2-interacting protein; Bcl-2-interacting protein beclin; beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like BCL2-interacting protein); beclin 1, autophagy related; Beclin-1; beclin1-beta; beclin1-gamma; BECN; coiled-coil myosin-like BCL2-interacting protein; coiled-coil, myosin-like BCL2-interacting protein; partial ORF; putative; testis secretory sperm-binding protein Li 215e; unnamed protein product
基因别名: ATG6; Beclin1; VPS30
UniProt ID: (Human) Q14457, (Rat) Q91XJ1, (Mouse) O88597
Entrez Gene ID: (Human) 8678, (Rat) 114558, (Mouse) 56208
autophagosome assembly
mitophagy
response to hypoxia
cytoplasmic pattern recognition receptor signaling pathway
autophagy
cellular response to nitrogen starvation
lysosome organization
mitotic metaphase plate congression
JNK cascade
circadian rhythm
negative regulation of cell proliferation
protein secretion
response to xenobiotic stimulus
response to iron(II) ion
response to lead ion
regulation of autophagy
negative regulation of autophagy
positive regulation of autophagy
positive regulation of cardiac muscle hypertrophy
macroautophagy
regulation of macroautophagy
response to nutrient levels
regulation of cytokinesis
receptor catabolic process
response to vitamin E
cellular response to amino acid starvation
phosphatidylinositol-3-phosphate biosynthetic process
p38MAPK cascade
cellular response to glucose starvation
negative regulation of apoptotic process
negative regulation of programmed cell death
engulfment of apoptotic cell
early endosome to late endosome transport
late endosome to vacuole transport
neuron development
beta-amyloid metabolic process
regulation of catalytic activity
response to other organism
bone development
SMAD protein signal transduction
positive regulation of stress granule assembly
protein-containing complex assembly
cellular response to hydrogen peroxide
cellular response to aluminum ion
cellular response to copper ion
cellular response to epidermal growth factor stimulus
cellular response to oxygen-glucose deprivation
autophagosome maturation
response to mitochondrial depolarisation
positive regulation of attachment of mitotic spindle microtubules to kinetochore
negative regulation of autophagosome assembly
negative regulation of lysosome organization
positive regulation of autophagosome assembly
positive regulation of intrinsic apoptotic signaling pathway
protein targeting to lysosome
cellular defense response
positive regulation of protein kinase B signaling
angiogenesis
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