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Invitrogen
Phospho-Cbl (Tyr674) Polyclonal Antibody
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产品信息
PA5-35704
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide derived from human CBL around the phosphorylation site of Tyrosine 674
偶联物
形式
Liquid
浓度
Lot-Specific
保存条件
-20°C
运输条件
Ambient
RRID
产品详细信息
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
靶标信息
Cbl proteins are a family of ubiquitin protein ligases (E3s) that negatively regulate signaling by targeting activated tyrosine kinases for degradation. Cbl- c is the most recently cloned member of the Cbl proteins and is expressed only in epithelial cells (the other Cbl proteins are ubiquitously expressed). Cbl-c, like the other mammalian Cbl proteins, can ubiquitinate the activated EGFR and target it for degradation. Through interactions with proteins containing SRC homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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