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Invitrogen
Phospho-DNA-PK (Ser2056) Polyclonal Antibody
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产品信息
PA5-38478
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthetic phosphopeptide derived from human DNA-PK around the phosphorylation site of Ser2056 (Y-S-SP-Q-D)
偶联物
形式
Liquid
浓度
1 mg/mL
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
PA5-38478 has been used successfully in peptide-ELISA at a dilution of 1:10,000.
靶标信息
DNA-PK is a heterotrimeric, DNA-dependent protein kinase that initiates signaling cascades in response to DNA damage. DNA-PK is an atypical kinase, closely related to the PI3 kinases, and is often potently inhibited by small molecules designed to target PI3 kinases. DNA-PK encodes a component of the mediator complex, a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for DNA-PK.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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