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Invitrogen
Phospho-EIF2S1 (Ser52) Polyclonal Antibody
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Phospho-EIF2S1 (Ser52) Antibody (PA1-26686) in IHC
Immunofluorescent analysis of Phospho-EIF2A pSer52 using a Phospho-EIF2A pSer52 polyclonal antibody (Product # PA1-26686). Left: rat brain (mediodorsal neocortex) sections following traumatic axonal injury (TAI) (24 h). Control (prior to injury induction) shows low basal levels of EIF2 alpha. Right: Image shows double labeling of APP (red) and EIF2 alpha (green) in neurons subjected to traumatic axonal inju... View More
产品信息
PA1-26686
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic phosphopeptide corresponding to a portion of human eIF-2 alpha containing serine 52. This portion is conserved among many species including rat, pig, cow, fruit fly and yeast.
偶联物
形式
Liquid
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
PA1-26686 detects eIF2A (phospho S52) from human and mouse samples. PA1-26686 is expected to cross react with a wide range of other species due to sequence homology.
PA1-26686 has been successfully used in Western blot procedures.
The PA1-26686 immunogen is a synthetic phosphopeptide corresponding to a portion of human eIF-2 alpha containing serine 52. This portion is conserved among many species including rat, pig, cow, fruit fly, and yeast.
靶标信息
EIF2a (Eukaryotic translation initiation factor 2A) is a heterotrimer composed of three subunits (alpha, beta, and gamma). This translation initiation factor drives binding of initiator methionyl-tRNA to the 40S ribosome in an AUG-dependent manner to form the 43S pre-initiation complex. The polypeptide can be phosphorylated by related protein kinases activated in response to stress. Phosphorylated EIF2A inhibits EIF2B activity and prevents guanine nucleotide exchange.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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