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Invitrogen
Phospho-ERK1/ERK3 (Thr202, Thr185) Recombinant Rabbit Monoclonal Antibody (K01_4Q55)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
MA567633
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
Expression System
HEK293F
分类
Recombinant Monoclonal
类型
Antibody
克隆号
K01_4Q55
抗原
A synthesized peptide derived from human Phospho-ERK1 (T202) + ERK2 (T185).
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
1 mg/mL
规格
100 µg
纯化类型
Protein A/G
保存液
PBS, pH 7.4, with 50% glycerol, 150mM NaCl, 0.05% BSA
内含物
0.02% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
ERK1 and ERK3 are members of the extracellular signal regulated kinase family within the mitogen activated protein kinase network. ERK1 is encoded by MAPK3 and functions as a classical kinase activated by the Ras Raf MEK cascade, controlling transcription factor activity, cell cycle progression, proliferation, differentiation, and survival through cytoplasmic and nuclear substrates. ERK3 is encoded by MAPK6 and is an atypical kinase with a distinct activation mechanism that relies on phosphorylation and protein stability, often forming complexes with MK5 also known as PRAK to regulate cell motility and stress responses. ERK1 exhibits robust oscillatory activation and nuclear shuttling upon growth factor stimulation, whereas ERK3 shows constitutive or context dependent regulation and subcellular localization patterns that differ from ERK1 and ERK2. Both kinases are implicated in cancer biology, developmental processes, and inflammatory signaling, and are evaluated with gene expression assays, phospho specific immunodetection, and functional studies using small molecule inhibitors or genetic perturbations.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ERK-1; ERK-3; Erk-3 related; ERT2; Extracellular signal-regulated kinase 1; Extracellular signal-regulated kinase 3; Insulin-stimulated MAP2 kinase; MAP kinase 1; MAP kinase 3; MAP kinase 6; MAP kinase isoform p44; MAP kinase isoform p97; MAPK 1; MAPK 3; MAPK 6; Microtubule-associated protein 2 kinase; mitogen activated protein kinase 4; mitogen activated protein kinase 6; mitogen-activated 3; mitogen-activated protein kinase 1; Mitogen-activated protein kinase 3; Mitogen-activated protein kinase 6; MNK1; p44 MAP kinase; p44-ERK1; p44-MAPK; p55-MAPK; p97-MAPK; pp42/MAP kinase; PRKM1; PRKM6; protein kinase, mitogen activated kinase 4
基因别名: 2610021I23Rik; D130053K17Rik; Erk-1; ERK1; ERK3; ERT2; Esrk1; MAPK1; MAPK3; Mapk4; MAPK6; Mapk63; MNK1; Mtap2k; p44; p44erk1; p44mapk; PRKM3; Prkm4; PRKM6
UniProt ID: (Rat) P21708, (Mouse) Q63844, (Mouse) Q61532, (Rat) P27704
Entrez Gene ID: (Rat) 50689, (Mouse) 26417, (Mouse) 50772, (Rat) 58840
phosphotyrosine binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
phosphatase binding
scaffold protein binding
nucleotide binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein kinase binding
protein heterodimerization activity
non-receptor serine/threonine protein kinase
MAPK cascade
MAPK import into nucleus
positive regulation of protein phosphorylation
transcription, DNA-templated
protein complex assembly
protein phosphorylation
apoptotic process
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
response to toxic substance
organ morphogenesis
phosphorylation
peptidyl-serine phosphorylation
sensory perception of pain
arachidonic acid metabolic process
BMP signaling pathway
lipopolysaccharide-mediated signaling pathway
response to lipopolysaccharide
regulation of stress-activated MAPK cascade
positive regulation of histone phosphorylation
positive regulation of histone acetylation
intracellular signal transduction
peptidyl-tyrosine autophosphorylation
response to exogenous dsRNA
positive regulation of translation
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
regulation of sequence-specific DNA binding transcription factor activity
cartilage development
regulation of cytoskeleton organization
lung morphogenesis
trachea formation
positive regulation of ERK1 and ERK2 cascade
interleukin-1-mediated signaling pathway
response to epidermal growth factor
cellular response to mechanical stimulus
caveolin-mediated endocytosis
regulation of Golgi inheritance
regulation of early endosome to late endosome transport
negative regulation of apolipoprotein binding
cell cycle
signal transduction
positive regulation of cyclase activity
ERK1 and ERK2 cascade
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